CCR5

(redirected from CKR-5)
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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
The report provides a snapshot of the global therapeutic landscape for C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5)
The report reviews C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Inhibition of HIV binding to the CKR-5 receptor is likely to be an effective therapy against HIV infection,'' Carrington said.
Among 612 people at high risk for HIV infection, 17, or 3 percent, had two mutant copies of the CKR-5 gene, the researchers reported.
People who inherit two copies of the mutant CKR-5 gene, one from each parent, cannot make the protein.
Discovery of CKR-5 and another co-receptor, fusin, was reported in June, quickly giving rise to the findings that the American and Belgian groups arrived at through different approaches.