KRT8

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KRT8

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that heteropolymerises to form intermediate filaments in epithelial cell cytoplasm. The KRT 8 typically dimerises with KRT 18 to form an intermediate filament in simple single-layered epithelial cells. KRT8  plays a role in maintaining cellular structural integrity, in signal
transduction and cell differentiation.

Molecular pathology
KRT8 mutations cause cryptogenic cirrhosis.
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References in periodicals archive ?
Only variable reactivity has been seen with CK7, CK8, CK18, and CK19.
Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review
Concurrently, in vivo exposure to EE, 25, and 250 [micro]g BPA/kg-BW significantly suppressed luminal progenitor markers (determined by alignment with CK8) (Figure 3B).
Evaluation of Bisphenol A (BPA) Exposures on Prostate Stem Cell Homeostasis and Prostate Cancer Risk in the NCTR-Sprague-Dawley Rat: An NIEHS/FDA CLARITY-BPA Consortium Study
The immunohistochemical stains gave positive results for cytokeratin 7 (CK7), cytokeratin 8 (CK8), estrogen receptor (ER) (strong, 99%), progesterone receptor (PR) (strong, 99%) (Figure 5), Smad4 (DPC4), GAtA binding protein 3 (GATA-3), gross cystic disease fluid protein 15 (GCDFP-15), and mammaglobin (Figure 6).
Diffuse Bone Marrow Metastasis as the Initial Presentation of an Occult Breast Cancer
Immunohistochemistry showed that those carcinoma cells were specifically positive for not only CK7 (Figure 1(f)) but also CK18 (Figure 1(f)) and c-kit (potential stem cells marker) [3, 5], whereas they were negative for CK8, Hepatocyte, and CD56.
Two Surgical Cases of Combined Hepatocellular-Cholangiocarcinoma, Intermediate-Cell Subtype: Potentially Characteristic Gross Features
The observed groundwater levels are from some wells including CK7 and CK8. And the measured solute concentrations are from well CK8.
Numerical Investigation into the Evolution of Groundwater Flow and Solute Transport in the Eastern Qaidam Basin since the Last Glacial Period
In the poorly-differentiated case of SCC, CK1 and CK10 were not expressed, but simple epithelial keratins (CK8, 18, and 19) were expressed.
Cutaneous squamous cell carcinoma complicating hidradenitis suppurativa: a review of the prevalence, pathogenesis, and treatment of this dreaded complication
Only four of the Food and Drug Administration (FDA)-approved markers (CA 15-3, CA 27.29, HER- 2/neu, and circulating tumor cells analysis of EpCAM, CD45, CK8, 18, 19) can be measured and assessed longitudinally.
Reliable Biomarkers to Identify New and Recurrent Cancer
The lining epithelia exhibited a negative expression pattern for CK8 and CK18.
Markers of proliferation and cytokeratins in the differential diagnosis of jaw cysts
The tumor cells were positive for HMB45, SMA, Melan-A (A103), vimentin and negative for CD117, CK7, CK8, CD10, and RCC.
Occult Renal Cell Carcinoma of Eosinophilic Morphology Detected within Renal Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex
AE1/AE3, Cam5.2) and low-molecular weight cytokeratins (CK7, CK8, CK19).
Mammary analogue secretory carcinoma (MASC) of the salivary gland: a new tumor entity
The stains showed diffuse +AFP, Glipan, and CK8; +Heppar in the solid areas; +CK17 and 19 in the glandular areas; -chromogranin, CD20, ER, PR, and GCDFP15; +luminal/focal polygonal CEA (Figures 2(a) and 2(b)).
A rare tumor in a patient with hepatic hydatic cyst: adrenal hepatoid adenocarcinoma

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