KRT5

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KRT5

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that is specifically co-expressed in the basal layer of the epidermis with family member KRT14.

Molecular pathology
KRT5 mutations are associated with epidermolysis bullosa simplex.
References in periodicals archive ?
These molecular subtypes showed different gene expressions: the Uro subtype expressed FGFR3 and cyclin D1 (CCND1), with the frequent loss of 9p21 (cyclin-dependent kinase inhibitor 2A [CDKN2A]); the genomically unstable subtype expressed Forkhead box Ml (FOXM1) but not CK5, with the loss of RB1; and the basal/SCCL subtype expressed CK5 and CK14, but not FOXA1 and GATA-binding protein 3 (GATA3).
A significant increase in basal progenitor markers (determined by alignment with CK5 expression) was observed in PS from rats exposed to EE and 25 [micro]g BPA/kg-BW in comparison with vehicle controls (Figure 3A).
Therefore, the panel of markers included CD117, DOG1 and CD34 for gastrointestinal stromal tumor (GIST), CK AE1/AE3, CK5, CK7, CK20, TTF-1 and p63 for carcinoma of digestive, pulmonary or squamous origin, Synaptophysin and Chromogranin A for neuroendocrine neoplasia, S100, Melan-A and HMB45 for malignant melanoma, HSA for hepatocellular carcinoma or hepatoblastoma, Vimentin and SMA for sarcoma and Ki-67 to evaluate the mitotic activity.
Navigational bronchoscopy and biopsy of the RUL lesion revealed squamous NSCLC with positive CK5, p63, and TTF-1 markers (Figures 1(a)-1(c)).
[13] CD10+, PSA- orifice, 3 cm Zamecnik and Epithelium: Within Hostakova [14] ER+, PR+, mesothelial CK5,6,7+, cyst of calretinin+, tunica EMA+ Stroma: vaginalis; PR+, 4 mm focus calretinin+, of endometriosis CD10+ found in 7 mm cyst Scully [15] Not reported Scrotum Scully [15] Not reported Scrotum Present CK7+, ER+, Right vas case CD10+, CD15+, deferens, GATA-3- 9.0 x 5.6 x 5.3 cm Source Treatment Followup Beckman Not Not et al.
3 Immunohistochemically, epithelium shows positive expressions of cytokeratins (CK), especially CK5, CK14, and CK19, and mesenchymal tumor cells show positive expression of nestin.
Epithelial components were stained by immunohistochemistry for cytokeratin 7, EMA, and vimentin, and less so for CK5, GFAP, NSE, and S-100 (Figure 2).
Also reported was a large inverted component, the presence of small nests of urothelial cells in the stalk, and the strong staining for CK5 and CD44.
Luminal cells in both humans and mice are characterized by the expression of low molecular weight cytokeratin (CK) 8 and 18, and androgen receptor (AR), while basal cells express the high molecular weight CK5 and p63 in both species [3,34,36-38].
Esta ultima categoria de TNP es dividida en dos subcategorias segun el tipo de moleculas basales que expone, denominandose como tumores del grupo basal nuclear (CBP) aquellos que expresan una de las citoqueratinas basales principales (CK5, CK6, CK14) o EGFR positivo (6-8), o recibiendo el nombre de tumores del fenotipo 5 negativo (5PN) pues carecen de marcacion celular (ER, PR, HER2, CK5/6 Y EGFR) (7).
CK5 is More Sensitive than CK5/6 in Identifying "Basal-like" Phenotype of Breast Carcinoma.