KRT13

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KRT13

A gene on chromosome 17q12-q21.2 that encodes a type-I intermediate filament keratin, which is expressed in corneal epithelia. KRT13 is paired with KRT4 and expressed in the suprabasal layers of non-cornified stratified epithelia.

Molecular pathology
KRT13 mutations are associated with autosomal dominant white sponge nevus.
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CK13 is also found to be useful in differentiating mucoepidermoid carcinoma from other salivary gland tumors.
La diferencia entre los fenotipos epiteliales corneales y conjuntivos se basa en la expresion de diferentes queratinas --mucinas--, siendo las citoqueratinas CK4 y CK13 las que se expresan en el epitelio conjuntival (10).
Cytokeratin (CK) Expression in Various Carcinoma Types of the Sinonasal Tract and Nasopharynx (a) AE1/AE3 CK5/6 CK7 CK8 CK13 SCC + + (9/10) + (6/10) + (9/10) + (9/10) NKSCC + + (9/10) - + (9/10) + (9/10) SNUC + - + (3/6) + (6/6) - NPC + + (4/5) - + (4/5) + (4/5) CK14 CK19 SCC + (8/10) + (9/10) NKSCC + (8/10) + (9/10) SNUC - + (3/6) NPC - + (5/5) Abbreviations: NKSCC, nonkeratinizing squamous cell carcinoma; NPC, nasopharyngeal carcinoma, undifferentiated type; SCC, squamous cell carcinoma; SNUC, sinonasal undifferentiated carcinoma.
2002), tambien observaron diferencias en la distribucion de la citoqueratina, especificamente la CK13, a nivel de los epitelios luminal y glandular.