KRT13

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KRT13

A gene on chromosome 17q12-q21.2 that encodes a type-I intermediate filament keratin, which is expressed in corneal epithelia. KRT13 is paired with KRT4 and expressed in the suprabasal layers of non-cornified stratified epithelia.

Molecular pathology
KRT13 mutations are associated with autosomal dominant white sponge nevus.
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In areas of squamous metaplasia seen in both squamous cell carcinoma and mucoepidermoid carcinoma, SCC is positive for CK10 and MEC for CK13. (57) CK10 is usually absent in these tumors, reflecting that true keratinization is an uncommon finding in mucoepidermoid carcinoma.
La diferencia entre los fenotipos epiteliales corneales y conjuntivos se basa en la expresion de diferentes queratinas --mucinas--, siendo las citoqueratinas CK4 y CK13 las que se expresan en el epitelio conjuntival (10).
Cytokeratin (CK) Expression in Various Carcinoma Types of the Sinonasal Tract and Nasopharynx (a) AE1/AE3 CK5/6 CK7 CK8 CK13 SCC + + (9/10) + (6/10) + (9/10) + (9/10) NKSCC + + (9/10) - + (9/10) + (9/10) SNUC + - + (3/6) + (6/6) - NPC + + (4/5) - + (4/5) + (4/5) CK14 CK19 SCC + (8/10) + (9/10) NKSCC + (8/10) + (9/10) SNUC - + (3/6) NPC - + (5/5) Abbreviations: NKSCC, nonkeratinizing squamous cell carcinoma; NPC, nasopharyngeal carcinoma, undifferentiated type; SCC, squamous cell carcinoma; SNUC, sinonasal undifferentiated carcinoma.
Olson et al., (2002), tambien observaron diferencias en la distribucion de la citoqueratina, especificamente la CK13, a nivel de los epitelios luminal y glandular.