KRT10

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KRT10

A gene on chromosome 17q21 that encodes a type-I (acidic) member of the cytokeratin family, which belongs to the superfamily of intermediate filaments, that with actin microfilaments and microtubules forms the epithelial cell cytoskeleton.

Molecular pathology
KRT10 mutations cause epidermolytic hyperkeratosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
(85,86) Interestingly, however, reduced expression of cytokeratin (CK) 1 and CK10 has been demonstrated by immunohistochemistry.
One spot corresponded to CK10. Later, the authors validated this marker by means of immunohistochemistry [143].
In the well-differentiated case of SCC, CK1 and CK10 expressions were downregulated, whereas CK14 expression was upregulated.
Other particles, whose role is still investigated and which may potentially have a prognostic value, are Ki-67, survivin, Bcl-2, Wnt proteins, metallothionein 2A, CCAAT, C/EBPs, C/EBP[alpha], and CK10 proteins, E-cadherins, and [beta]-catenin, as well as p16, p53, EGFR proteins, cyclin D1, and PLUNC (palate, lung, and nasal epithelium clone protein) (Table 3).
In a case series of four tumors, the authors reported intense and diffuse positivity for CK7, variable expression of epithelial membrane antigen (EMA), vimentin, S100, Ulex europaeus antigen, high-molecular weight CK, CK 8, CK 18 and CK19, and diffuse negativity for carcinoembryonic antigen (CEA), CD15, CD34, desmin, actin, CK10, CK20 and HMB45 [15].
El grupo 4 es claramente el perfil de los sitios Llolleo del sureste de Colonia Kennedy y Peuco (CK1/6, CK10, CK11, EP) y el grupo 5 de los sitios de mas al norte cercanos al estero La Berlina, tanto Bato como Llolleo (CK2, CK3, CK4).
Mucoepidermoid carcinoma also expresses CK7, 8, and 19 and negative for CK10. In areas of squamous metaplasia seen in both squamous cell carcinoma and mucoepidermoid carcinoma, SCC is positive for CK10 and MEC for CK13.
In all samples, the score for CK10 was 3, which implied a housekeeping function that potentially can be used for sample normalization.
The monoclonal antibody 34[beta]12 targets cytoplasmic highmolecular-weight cytokeratin filaments in basal cells of the benign prostatic glands, namely CK1, CK5, CK10, and CK14.62 p63 is a nuclear stain for the p63 nuclear protein, which selectively stains basal cell nuclei and may provide greater specificity compared with 34[beta]12, which is more likely to have nonspecific reactions.
Antibodies to a number of basal-type and highmolecular-weight cytokeratins, including cytokeratin (CK) 1, CK5, CK5/6, CK10, CK14, and CK17, react variably with breast MECs.
The antibody 34pE12 identifies a cocktail of acidic and basic CK, including CK1, CK5, CK10, and CK14.