KRT3

(redirected from CK-3)

KRT3

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin, specifically expressed in the corneal epithelium.
 
Molecular pathology
KRT3 mutations are associated with Meesmann's corneal dystrophy.
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References in periodicals archive ?
Table 1: Tissue Distribution of CK Isoenzymes CK-1 CK-2 CK-3 (BB) (MB) (MM) Skeletal 0 1 99 Cardiac 1 20 79 Brain 97 3 0 Table 2: Troponin Elevations in Patients Without Overt Ischemic Heart Disease Acute rheumatic fever Hypotension, often with Amyloidosis arrhythmias Cardiac trauma (including Hypothyroidism contusion, surgery, ablation) Inflammatory disease Cardiotoxicity from (including myocarditis, chemotherapy bacterial endocarditis, Chronic renal failure Kawasaki disease) Heart failure Acute neurological diseases Critically illness Post-operative non-cardiac Diabetes surgery Drug toxicity Pulmonary embolism, Hypertension severe pulmonary hypertension Sepsis
This Committee has tested all Ontario laboratories licensed to determine creatine kinase (CK; EC 2.7.3.2) and CK isoenzyme-2 (CK-2 or CK-MB) since 1989 [2] with lyophilized human-based serum, and, from 1991 onwards, with fresh frozen human serum supplemented with purified human CK-3 (CK-MM) and CK-2 [3].