KRT20

(redirected from CK-20)

KRT20

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that is a major cellular protein of mature enterocytes and goblet cells, and is specifically expressed in gastric and intestinal mucosa.
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Results of immunohistochemical staining Immunostain Result Bcl2 Negative c-erbB2 Negative (1+) Cyclin D1 Positive EGFR Positive (2+) Ki-67 60% P53 Positive AMACR Negative CK-7 Negative CK-20 Positive CDX-2 Positive TTF-1 Negative
Immunohistochemical staining of liver tissue was positive for CK-7, p63 and p40 and negative for TTF-1, CK-20 and CDX-2, confirming SCC of lung as primary malignancy (Figure 6).
primary Low-grade FDG uptake in right axillary nodes No metabolically active lesion seen to suggest a possible primary neoplasm Minimal free fluid seen in POD Repeat bone marrow Neoplastic cells express CK-7, GCDFP-15, biopsy with IHC ER, PR, CK 19 Negative to CK-20, CDX-2, CEA, mammoglobin, TTF-1, CA-125, CA-19-9 Impression: metastatic carcinoma, consistent with primary site in breast Gastro duodenoscopy Fundic gastritis Duodenal lesion as above GIST?
MHK, histolojik olarak CK-20 ve diger noroendokrin belirteclerin pozitif bulundugu malin kucuk hucreler ile karakterize primer bir noroendokrin karsinomdur.
The epithelial component showed variable positivity, in different areas, for cytokeratin (CK)-7 and CK-20.
Kato and associates presented a case of CK-20 positive large cell neuroendocrine carcinoma suggesting a link between colonic adenocarcinoma and large cell neuroendocrine carcinomas as CK-20 is normally associated with colonic adenocarcinoma.