CITED4

CITED4

A gene on chromosome 1p34.1 that encodes a member of the CITED (CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain) family of proteins which acts as transcriptional coactivator for TFAP2/AP-2. CITED4 enhances oestrogen-dependent transactivation mediated by oestrogen receptors. It may inhibit transactivation by HIF1A by disrupting HIF1A interaction with CREBBP, and it may play a role in regulating gene expression during development and differentiation of haematopoietic, endothelial and breast epithelial cells. It is highly expressed in the heart, liver, skeletal muscle and pancreas; it is downregulated in breast tumours. Downregulation of expression is associated with increased HIF1A, tumour growth and angiogenesis.
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According to the authors cited4, if only the results with statistical significance of well controlled clinical studies are examined, only two reviews agree with the results obtained by the AHA, while all the other analyzes give contrary results.
Accenture and Babson College (2004) 'The Drug Industry's Aliance Archipelago', (online) (cited4 May 2010).