SOCS2

(redirected from CIS2)

SOCS2

A gene on chromosome 12q that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS2 expression is induced by cytokines (e.g., erythropoietin, CSF2/GM-CSF, IL10 and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling. SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in regulating IGF1R-mediated cell signalling.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The other metabolites are trans-3(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (TDCCA) and cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (CDCCA), which are metabolites of permethrin, cypermethrin, cyfluthrin; cis2,2-dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA), which is a metabolite of deltamethrin; and 4-fluoro-3-phenoxybenzoic acid (4F3PBA), a metabolite of cyfluthrin.
Using two consecutive waves of the Community Innovation Survey (CIS) (CIS2 and CIS3) for ten European countries, Mastrostefano and Pianta (2009) concluded that new products' sales (both in levels and in percentage changes) are a significant, positive determinant of employment change, along with a positive (negative) influence of demand (wages).
"Financial Constraints to Innovation in the U.K: Evidence from CIS2 and CIS3." allord Economic Papers, 60(1): 711-730.
Emotional maltreatment in Canada: Prevalence, reporting and child welfare responses (CIS2).
Financial constraints to innovation in the UK: evidence from CIS2 and CIS3, Oxford Economic Papers 60(4): 711-731.
Emotional maltreament in Canada: Prevalence, reporting and child welfare responses (CIS2).
(110.) An EU survey (EUROSTAT -- CIS2) shows that the proportion of firms introducing innovations rises from 44 per cent for firms with 20-49 employees to 79 per cent for those with more than 500 employees.