BCL10

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BCL10

A gene on chromosome 1p22 that encodes a protein which contains a caspase recruitment domain (CARD); it induces apoptosis, activates NF-kappaB and interacts with other CARD domain proteins (e.g., CARD9, 10, 11 and 14), which are thought to act as upstream regulators in NF-kappaB signalling.

Molecular pathology
BCL10 protein product forms a complex with MALT1, a protein encoded by a gene that is translocated in MALT lymphoma and together activate NF-kappaB; deregulation of either BCL10 or MALT1 may lead to MALToma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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[4] En la epoca se dieron a conocer el caso de desvio de recursos desde una entidad estatal dedicada a promover el deporte (ChileDeportes), y la existencia de facturas falsas en la campana del senador del PPD Guido Girardi con la empresa Publicam (CIPER 2015).
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(1) University of Lisbon, Faculty of Human Kinetics, CIPER, LBMF, 1499-002 Lisbon, Portugal
Degree), researcher of CIPER, for statistical guidance.