As shown in Figure 9, a downregulation of P21 (also known as cdkn1a or Cip1
), a cell cycle inhibitor, is also involved in cell apoptosis and transcriptional regulation after DNA damage [29-31] (Figures 9(a) and 9(b)) and BAK, a proapoptotic protein, were observed at protein levels in HW-treated irradiated mice c-kit+ cells (Figures 9(e) and 9(f)).
Hida et al., "RXR antagonism induces [G.sub.0]/[G.sub.1] cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 Cip1
equation image pathway in adipocytes," Journal of Pathology, vol.
Module Size GSCA .p Hub and DCGs Black 599 0 GJA8, LOC421988, MYOCD Magenta 357 0 C10orf83, PPME1, NRTN, TMEM167B, ABCA5, C10orf58 Salmon 248 0 CPA5, PRSS2, ARHGEF19, INS, CELA2A, TCERG1L, LOC396296, LOC771434, KCNC2, XKR9 Lightcyan 155 5.55E-16 LOC769741, TRPA1, C10orf96, CASKIN2, GMCSF, cor6 Brown 1349 2.11E-09 -- Cyan 181 1.77E-08 RAB36, LOC415324, UPK3B, CWH43 Lightgreen 145 4.05E-07 CIP1
, ZC3H12D, TNS3, SOCS3, LOC415844 Pink 418 4.20E-07 ABCG8 Lightyellow 126 2.10E-05 DEPDC1, CDCA2 Tan 287 2.23E-04 TP53INP1, CNRIP1, NEURL, SEPP1 Midnightblue 159 1.16E-02 LOC416257 Greenyellow 293 2.04E-01 INVS, ARSH Grey60 145 2.10E-01 -- Purple 298 2.51E-01 WDR5, NIPA2 Red 648 8.66E-01 -- Blue 2581 1 -- Green 1056 1 -- Turquoise 2998 1 -- Yellow 1122 1 -- Note.