CDKN1A

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CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.
References in periodicals archive ?
When asked if the department had hired planners from Italian backgrounds to do outreach, the planner admitted, "that probably would've been a good idea" although language translation was provided (CIP1, December 6, 2005).
The researchers screened for CIP1 by adding different pieces of human DNA to genetically engineered yeast.
Roberts, "N-acetylation and ubiquitin-independent proteasomal degradation of p21 Cip1," Molecular Cell, vol.
Connolly, "p21(cip1) rescues human mesenchymal stem cells from apoptosis induced by low-density culture," Cell and Tissue Research, vol.
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
As shown in Figure 9, a downregulation of P21 (also known as cdkn1a or Cip1), a cell cycle inhibitor, is also involved in cell apoptosis and transcriptional regulation after DNA damage [29-31] (Figures 9(a) and 9(b)) and BAK, a proapoptotic protein, were observed at protein levels in HW-treated irradiated mice c-kit+ cells (Figures 9(e) and 9(f)).
Hida et al., "RXR antagonism induces [G.sub.0]/[G.sub.1] cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 Cip1 equation image pathway in adipocytes," Journal of Pathology, vol.
Effects of p21 (Cip1 /Waf1) at both the G(1)/S and the G(2)/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (vol 18, pg 629, 1998).
Flow cytometric analysis of reverse transcription-PCR products: quantification of p21(WAF1/ CIP1) and proliferating cell nuclear antigen mRNA.
Module Size GSCA .p Hub and DCGs Black 599 0 GJA8, LOC421988, MYOCD Magenta 357 0 C10orf83, PPME1, NRTN, TMEM167B, ABCA5, C10orf58 Salmon 248 0 CPA5, PRSS2, ARHGEF19, INS, CELA2A, TCERG1L, LOC396296, LOC771434, KCNC2, XKR9 Lightcyan 155 5.55E-16 LOC769741, TRPA1, C10orf96, CASKIN2, GMCSF, cor6 Brown 1349 2.11E-09 -- Cyan 181 1.77E-08 RAB36, LOC415324, UPK3B, CWH43 Lightgreen 145 4.05E-07 CIP1, ZC3H12D, TNS3, SOCS3, LOC415844 Pink 418 4.20E-07 ABCG8 Lightyellow 126 2.10E-05 DEPDC1, CDCA2 Tan 287 2.23E-04 TP53INP1, CNRIP1, NEURL, SEPP1 Midnightblue 159 1.16E-02 LOC416257 Greenyellow 293 2.04E-01 INVS, ARSH Grey60 145 2.10E-01 -- Purple 298 2.51E-01 WDR5, NIPA2 Red 648 8.66E-01 -- Blue 2581 1 -- Green 1056 1 -- Turquoise 2998 1 -- Yellow 1122 1 -- Note.
Cip1, or Sdi 1) is the founding member of the Cip/Kip family of cyclin-dependent kinase inhibitors, which also includes p27 (el-Deiry et al.