IGF2R

(redirected from CI-MPR)

IGF2R

A gene on chromosome 6q26 that encodes a receptor for both insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). IGF2R plays a role in intracellular trafficking of lysosomal enzymes, activating transforming growth factor beta, IGF2 degradation and regulating T-cell coactivation by binding DPP4.
References in periodicals archive ?
Cation-independent receptors (CI-MPR) consist of 15-repeated mannose 6-phosphate receptor homology (MRH) domains in the luminal portion, followed by a transmembrane domain and a cytoplasmic domain.
By contrast, AP-2 adaptin binds to CI-MPR on cell surfaces and forms endocytic vesicles in combination with other different coat proteins.