VSX2

(redirected from CHX10)
Also found in: Acronyms.

VSX2

A gene on chromosome 14q24.3 that encodes a homeobox protein which plays a key role in the specification and morphogenesis of the sensory retina. It may participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.

Molecular pathology
VSX2 mutations are associated with microphthalmia, cataracts and iris abnormalities.
References in periodicals archive ?
number Dilution Source OCT4 Abcam ab18976 1/250 Rabbit NANOG Abcam ab21624 1/100 Rabbit SSEA4 Abcam ab16287 1/100 Mouse TRA-1-81 Abcam ab16289 1/100 Mouse TRA-1-60 Abcam ab16288 1/100 Mouse SOX1 Abcam ab87775 1/200 Rabbit PAX6 DSHB 3B5 1/50 Mouse OTX2 Abcam ab21990 1/500 Rabbit LHX2 Santa Cruz sc-81311 1/200 Mouse Biotechnology SIX3 Rockland 600-401-A26 1/500 Rabbit MCM2 Abcam ab4461 1/400 Rabbit CHX10 Millipore ab9016 1/200 Sheep FIBRONECTIN Abcam ab2413 1/200 Rabbit ZO-1 Thermo Fisher 33-9100 1/400 Mouse BRN3 Santa Cruz sc-6026 1/200 Goat Biotechnology AP2 DSHB 3B5a 1/35 Mouse PROX1 Abcam ab101851 1/2000 Rabbit PKC-[alpha] Abcam ab32376 1/2000 Rabbit CRALBP Abcam ab15051 1/500 Mouse Rhodopsin Abcam ab3267 1/200 Mouse S opsin Gift from Dr.
Immunoblots showed that Chx10 content significantly increased in LD, MD, and HD GLE retinas by 18.3 [+ or -] 1.6%, 31.4 [+ or -] 2.8%, and 20.4 [+ or -] 3.1%, respectively (Figure 2B).
Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators.