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The extended agreement enables Cantargia to create and use additional CHO cell lines engineered using POTELLIGENT Technology and develop and commercialize CAN04 made through such CHO cell line.
In addition to developing a robust and highyield process, such as the CHO cell line producing titers >6g/L as shown in Figure 1, cost pressures can be managed through process fitting experiments that help reduce a molecule's manufacturing footprint.
Lead anti-mICOSL and anti-hICOSL VNAR-Fc proteins were tested for binding to the CHO cell surface expressed ICOSL and their corresponding efficacy in an ICOS/ICOSL blocking assay.
"The analysis of glycans derived from monoclonal antibody (mAb), blood proteins (Fetuins), CHO cell lines etc.
Improvement of CHO cell culture medium formulation: Simultaneous substitution of glucose and glutamine.
(2012) IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines.
A complete set of CG analyses by cell-fusion between 12 CGs of CHO cell mutants and 13 CGs of fibroblasts from patients with PBDs revealed that 11 CGs of CHO mutants represent the human PBD CGs (5),(29) (Table 3).
CHO cell lines stably transfected with human FSHR have been described previously (Bonomi et al.
The full-length genomic sequence of strain Bari/212/07/ ITA shared 89%-90% nt identity with sequences of viruses identified as CHO cell contaminants; it shared only 71.0% nt identity with the prototype CaCV strain 48.
Under the agreement, Rodon will engineer a high-yielding cho cell line expressing CAB102, along with the processes necessary to manufacture and formulate the drug for the first in-human trials.
The parameters for [[sup.3]H]CP55940 binding to [hCB.sub.1] and [hCB.sub.2] CHO cell membranes have been determined by fitting data from saturation binding experiments to a one-site saturation plot using GraphPad Prism 5.
In the past decade, numerous companies and academic groups have focused significant efforts on using genomic, proteomic, and transcriptomic studies to generate a complete understanding of CHO cell biology under different conditions.
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