CHN2


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CHN2

A gene on chromosome 7p15.3 that encodes chimerin 2, a GTPase-activating protein which is regulated by phospholipid binding. Binding of diacylglycerol (DAG) induces translocation of CHN2 from the cytosol to the Golgi membrane; it plays a role in smooth muscle cell proliferation and migration.

Molecular pathology
CHN2 expression is reduced in high-grade gliomas and breast tumours, and increased in certain lymphomas.
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2.3.4 Quanttative PCR detection of CHN2 gene promoter methylation
The Pearson method was used to analyze the correlation between CHN2 methylation levels and other factors, including the age of starting taking MA, the total duration of MA use, and combination with other psychoactive substances.
As shown in Figures 2 and 4, the mean (sd) methylation levels of the CHN2 gene promoter in the case group were significantly higher than in the control group, which were 2795.55 (733.19) and 1026.73 (698.73), respectively, showing significant differences between the two groups (t=21.25, p<0.001).
Abnormal methylation of CHN2 gene can lead to the expression changes of chimeric protein-2.
In addition, the samples selected for this study were all male, and the methylation levels of CHN2 gene promoter may have differences between genders.
Chimeric protein 2 (CHN2) regulating Rac GTPase activity is the receptor for diglyceride and phorbol ester.
This research showed that long-term MA addiction caused the methylation changes of CHN2 gene promoter.