FOXN3

(redirected from CHES1)

FOXN3

A gene on chromosome 14q31.3 that encodes a member of the forkhead family of transcription factors, which is thought to suppress cell cycle checkpoint mutations by activating an MEC1-independent checkpoint pathway.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
In BD, important genetic variants that could be affected by shiftwork either directly or indirectly are Del, ANK3 rs1938526, COMT Val158Met, DAOA, BRD1/ ZBED4, BDNF Val66Met, BRD1, ASMT, CAMTA1, CCDC132, CHES1, DGKH, DRD4, HTR1A C1019G, SLC6A4, 5-HTTLPR PARD3B, PDLIM5, STin2 VNTR, KLHL3, LYPD5, MAOA T941G, MTHFR A1298C and C677T, TPH1 STAB1, HTR3B, and WNK2 [95].
(25) Deletion of chromosome 14 extending from the q24 to q31 band encompasses additional candidate genes involved in tumorigenesis, including SEL1L (the human ortholog of the C elegans sel-1 suppressor enhancer of lin-12), CHES1 (checkpoint suppressor 1), and MAP3K9 (mitogen activated protein kinase kinase kinase 9) genes.
Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1. Int J Cancer.