CALCA

(redirected from CGRP1)

CALCA

A gene on chromosome 11p15.2 that encodes peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin, by tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor peptides. Calcitonin regulates calcium and phosphorus metabolism; calcitonin gene-related peptide is a vasodilator; katacalcin is a calcium-lowering peptide.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Interaction of CRLR with RAMP1 forms the CGRP1 receptor, which has greater affinity for CGRP than for AM, whereas association with RAMP2 or RAMP3 gives rise to the AM preferring receptors 1 and 2, respectively.
Binding of CGRP to CGRP1 receptors in the rat spinal cord produces hyperalgesia through a mechanism involving activation of PKA and PKC signaling pathways [219].
Interventions that were found to have some beneficial effect in preclinical studies include non-NMDA and NMDA receptor antagonists, mGluR1 and mGluR5 antagonists, agonists for group II mGluR2/3 and group Ill mGluR, including mGluR8, antagonists for CGRP1 and CRF1 receptors, neuropeptide S activating NPS receptors, and inhibitors of ERK and PKA (reviewed in [7]).
Especificamente, resultados recientes mostraron la presencia de AM y los componentes de su receptor en el vermis cerebeloso de ratas WKY y SHR, indicando la presencia de receptores del peptido relacionado al gen de la calcitonina 1 (CGRP1), AM tipo 1 (AM1) y AM tipo 2 (Am2) en esta area (11,18-21, 29,30).
The association of another G protein-coupled receptors (GPCRs), the calcitonin receptor-like receptor (CLR), and RAMP1 generates the [[alpha]-CGRP.sub.8-37] sensitive CGRP1 receptor.
Pharmacology of the human CGRP1 receptor in Cos 7 cells.
Through binding to the CGRP1 receptor, ADM further elevates cAMP levels in vascular smooth muscle cells and expands blood vessel diameter.
Calcitonin gene-related peptide-induced suppression of atrial natriuretic peptide release through receptors for CGRP1 but not for calcitonin and amylin.
El CLR tiene varias alternativas farmacologicas que son conferidas por las RAMPs, RAMP1 produce un receptor tipo 1 del peptido relacionado con el gen de la calcitonina (CGRP1), mientras que RAMP2 y RAMP3, generan receptores de ADM (12).
En relacion al efecto vasodilatador de la ADM la mayoria de los datos indican que esta induce relajacion independiente de endotelio, al actuar sobre receptores CGRP1 y elevar los niveles de AMPc en las celulas del musculo liso vascular.
The activation of peripheral nerve endings via these receptors [74] ultimately results in the local release of several neurotransmitters and neuropeptides (substance P and calcitonin gene-related peptide 1 (CGRP1)), which have strong vasodilatory and chemotactic properties [110].