CGRP


Also found in: Acronyms.

CGRP

CALCA

A gene on chromosome 11p15.2 that encodes peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin, by tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor peptides. Calcitonin regulates calcium and phosphorus metabolism; calcitonin gene-related peptide is a vasodilator; katacalcin is a calcium-lowering peptide.

CGRP

Abbreviation for calcitonin gene-related peptide.
References in periodicals archive ?
Biohaven is also developing its product candidate BHV-3500, the first small molecule CGRP receptor antagonist to be administered in an intranasal (IN) formulation in human testing.
"New research shows that CGRP, which is a neuropeptide, has a central role in the pathophysiology of migraine," says Dr Karoly Zoltan Vadasdi, Neurology Specialist, Canadian Specialist Hospital.
The three CGRP inhibitors that are already approved by the FDA are all injected drugs that are used regularly to prevent migraine attacks.
The second compound lowered by CoQ10 is calcitonin gene-related peptide (CGRP).
It does not completely eliminate migraine headaches, but "CGRP monoclonal antibody antagonists will help many people with such a devastating disabling disease as migraine," Dr.
Lipton also presented the results of ACHIEVE II, a multicenter, double-blind, phase 3, placebo-controlled study of the oral CGRP receptor antagonist ubrogepant at 25 mg or 50 mg versus placebo in 1,355 patients with episodic migraine.
Researchers have been working on finding an antidote to CGRP for over 30 years and came up with an antibody which, because it persists in the body, only needs to be taken once a month by injection.
for Biohaven's small molecule calcitonin gene-related peptide (CGRP) receptor antagonist platform, which includes rimegepant, a potential candidate for the acute treatment of migraine, and BHV-3500, a third-gen antagonist for the acute treatment and prevention of migraine.
Calcitonin gene-related peptide (CGRP) is a neurotransmitter produced by neurons in the brain.
Tissues were collected from the dorsal root ganglia (DRGs) to quantify the pain-recognition receptor, TRPA1, in parallel with the marker of tumor progress and the pain transducer, CGRP, and to study the underlying molecular mechanisms.
Proper sensory perception is conditioned by a functional balance between nociceptive substances such as substance P (SP) or calcitonin gene-related peptide (CGRP) and, on the other hand, an appropriate level of antinociceptive factors, particularly the opioid family, for example, leu5-enkephalin (L-ENK) [14-17].