CAV1

(redirected from CGL3)

CAV1

A gene on chromosome 7q31.1 that encodes caveolin 1, the main scaffolding protein of caveolae plasma membranes in most cells. Caveloin 1 links integrin subunits to the tyrosine kinase FYN, an early step in coupling integrins to the Ras-ERK pathway which drives cell cycle progression; CAV1 is a tumour suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and form a stable hetero-oligomeric complex with other colocalising proteins.

Molecular pathology
CAV1 mutations are linked to congenital generalised lipodystrphy (Berardinelli-Seip syndrome) type 3.
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References in periodicals archive ?
Several responsible genes have been identified: 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2, CGL1) (3), Berardinelli-Seip congenital lipodystrophy 2 (BSCL2, CGL2) (4), caveolin 1 (CAV1, CGL3) (5), and polymerase I and transcript release factor (PTRF, CGL4) (6, 7).
and Thore, S., Structural basis for chitotetraose coordination by CGL3, a novel galectin-related protein from Coprinopsis cinerea.
These include the: 1.3 L CGl3, gasoline and LPG engines; the gasoline and LPG H15 family (1.5 L); the 1.5 LA15 engines in gasoline and LPG configurations; and the 4.2 L TB42 gasoline and LPG engines, as well as the H20 and H25.