cystic-fibrosis-related diabetes

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cystic−fibrosis-related diabetes

Abbreviation: CFRD
DM arising in patients with cystic fibrosis (CF). It is the most common complication of CF other than those conditions that affect the lungs. It is caused by destruction of islet cells (the cells in the pancreas that make insulin) as well as a decrease in sensitivity of the liver and muscles to the actions of insulin. The disease usually first becomes clinically obvious in young adults.

Patient Care

Although CFRD can be diagnosed with fasting glucose blood tests or hemoglobin A1c levels, many experts recommend using an oral glucose tolerance test. Fifteen to thirty percent of patients with CF are affected by their 20th birthday, and perhaps as many as half have the disease by age 30. CFRD is associated with more severe lung disease than is experienced by patients with CF and normal glucose tolerance. Oral hypoglycemic agents, insulin, and exercise are the primary methods of treatment. Caloric restriction, a cornerstone of treatment for other forms of diabetes, is relatively contraindicated because of the need for aggressive nutritional supplementation in CF patients.

See also: diabetes
References in periodicals archive ?
"It's great to hear that researchers are focusing on helping people with CFRD as it could benefit patients in the future.
Because the creep deformation of the rockfill occurs while the load is applied, the creep is analysis for the whole period of the CFRD construction and operation process.
Katie Larson Ode, a pediatric diabetologist at the University of Iowa, Iowa City, that showed that abnormal glucose tolerance was already present in 41% of children with CF at ages 6-9, and that those children had a high rate of early-onset CFRD (Pediatr.
The model parameters are consistent with those used in the simulation of the construction process of the Zipingpu CFRD, and the capacity of the constitutive model in describing the virgin loading, unloading, and reloading and cyclic loading responses of the Zipingpu rockfill material is demonstrated in the previous paper [11,12].
While diabetes is also strongly associated with the development of cataracts, (58,64) the effect of CFRD on the lens in CF is yet to be determined.
The cracking of the concrete slab is the most important factor affecting the safety of concrete-faced rockfill dams (CFRDs).
It's important to bear in mind, however, that glycosylated hemoglobin measurements may underestimate the degree of abnormal glucose metabolism in patients with CFRD. That's because they have increased red blood cell turnover, which dilutes the Hb[A.sub.1c], he explained at the conference sponsored by the university and the Children's Diabetes Foundation at Denver.
"3-D authentic nonlinear method for dynamic analysis of high CFRD", Journal of Water Conservancy, (9).
In CFRD with hyperglycemia, both the fasting glucose and the postprandial blood sugar are high.
These officers were invited to apply to the temporary CFRD set up in Prince George for assessment and assignment to positions within the Rocky Mountain Rangers.
In hyperglycemic CFRD subjects, PTI-801 led to a statistically significant normalization of glucose levels at the three dose levels analyzed.