cystic-fibrosis-related diabetes

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cystic−fibrosis-related diabetes

Abbreviation: CFRD
DM arising in patients with cystic fibrosis (CF). It is the most common complication of CF other than those conditions that affect the lungs. It is caused by destruction of islet cells (the cells in the pancreas that make insulin) as well as a decrease in sensitivity of the liver and muscles to the actions of insulin. The disease usually first becomes clinically obvious in young adults.

Patient Care

Although CFRD can be diagnosed with fasting glucose blood tests or hemoglobin A1c levels, many experts recommend using an oral glucose tolerance test. Fifteen to thirty percent of patients with CF are affected by their 20th birthday, and perhaps as many as half have the disease by age 30. CFRD is associated with more severe lung disease than is experienced by patients with CF and normal glucose tolerance. Oral hypoglycemic agents, insulin, and exercise are the primary methods of treatment. Caloric restriction, a cornerstone of treatment for other forms of diabetes, is relatively contraindicated because of the need for aggressive nutritional supplementation in CF patients.

See also: diabetes
References in periodicals archive ?
The recalculated displacement values of Shuibuya CFRD using the inversed rockfill model parameters are shown in Figures 7-9.
Caption: Figure 1: Rockfill material zone and construction progress of the Shuibuya CFRD.
Evidence-based guidelines for CFRD put forth jointly by the American Diabetes Association, Cystic Fibrosis Foundation, and Lawson Wilkins Pediatric Endocrinology Society (Diabetes Care 2010;33:2697-2708) emphasize that, unlike in patients without CF, the diagnosis of CFRD can be made while a patient is hospitalized with an acute illness.
While there are no published studies on visual function levels in CFRD subjects, there is substantial evidence that dark adaptation, (99-102) colour vision, (103,104) and contrast sensitivity104 are adversely affected in type 1 and type 2 diabetes, even in the absence of DR.
It is, therefore, important that CF patients are advised to have regular eye examinations, and those with CFRD to attend annual retinal screening.
Oral Glucose Tolerance Categories in Cystic Fibrosis 2-Hour Fasting Postprandial Category mg/dL mg/dL Normal glucose tolerance <126 140 (NGT) Impaired glucose tolerance <126 140-199 (IGT) CFRD without fasting <126 -200 hyperglycemia CFRD with fasting [> or =] 126 Oral glucose hyperglycemia tolerance test not necessary Adapted from Cystic Fibrosis Foundation (1999a).
The CFRD sections consist of different material partitions.
The water pressure on the upstream panel can be directly determined by considering the structure and state of workability of CFRD.
Another approach to preventing CFRD is being pursued by her colleague, Dr.
The peak age of onset for CFRD is 20-24 years, whereas type 1 diabetes is more common in children and type 2 diabetes is more common in mid-to-late adulthood, she said.
They are very well aware, for example, that the life expectancy of women with CFRD is 17 years less than in CF patients without diabetes, and they are hopeful that excellent diabetes management will give them back some of those years.