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We identified 6 studies in which both PCV and AMD were assessed for associations with a total of 7 SNPs in 5 genes (i.e., CETP rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, ABCA1 rs1883025, and ABCG1 rs57137919) (Table 3 and Figure 3).
Antibodies against rabbit CETP (1 : 400; Abcam, Cambridge, UK), human CETP (1 : 400; Abcam, Cambridge, UK), and GAPDH (1 : 500; Beyotime, Beijing, China) were used for Western blot analysis.
* The report reviews Cholesteryl Ester Transfer Protein (Lipid Transfer Protein I or CETP) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
In past reports, the only other CETP inhibitors to complete phase III trials either showed no incremental benefit like evacetrapib, which happened with dalcetrapib (N Engl J Med.
The genotype frequencies observed for CETP I405V among the study population was compatible with the Hardy-Weinberg equilibrium (HWE) expectations (HWE [chi square] = 1.72, p = 0.189).
And Amgen announced in September that it would pay at least $300 million to buy Dezima Pharma, a privately held Dutch company that has a CETP inhibitor ready to enter the final stage of clinical testing.
We mixed clarified sample supernatants with 55 jL of 10X radioimmunoprecipitation assay (RIPA) lysis buffer (EMD Millipore Corp.), protease inhibitors (EMD Millipore Corp.), and IA beads for both CETP and PCSK9 (0.6 mg each/sample).
KATI had requested the government for help because individual industrialists did not have enough funds or space for treatment plants as CETPs need huge sums.
military training facilities in Europe under the Combined Education and Training Program (CETP) which includes the International Military Education and Training Program (IMET), the George C.
Using the genotypic model in the overweight group, we identified a SNP within the CETP gene on chromosome 16 (rs5880) that was associated with CAD at a significance level of 0.008 (Table 5).
The data are comparable with those recently achieved by two other CETP inhibitors under investigation, anacetrapib and dalcetrapib.
Anacetrapib belongs to a new class of medications known as cholesterylester transfer protein (CETP) inhibitors, which block the ability of an enzyme (CETP) to transfer cholesterol particles from HDL to LDL.