CES1


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CES1

A gene on chromosome 16q22.2 that encodes a member of the carboxylesterase family, which hydrolyse or transesterify xenobiotics (e.g., cocaine and heroin) and endogenous substrates with ester,
thioester or amide bonds. CES1 may participate in fatty acyl and cholesterol ester metabolism, and may play a role in maintaining the blood-brain barrier. It is the major liver enzyme and functions in liver drug clearance.
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On the other hand, there are also drugs which can increase or decrease the level of clopidogrel active metabolite by the inhibition or induction of the CES1 enzyme [43].
Besides, although it might be with considerably minimal effect, the synergetic effect of other genetic variabilities such as the PON1, the CYP3A4/5, the ABCB1, the P2Y12 receptors, and the CES1 cannot be neglected [20, 22-24, 40].
11 (CYP3A11) Carboxylesterase 1 (CES1) 57013389 1.20 0.00 Glutamate-ammonia ligase, 145559476 0.80 0.00 glutamine synthetase (GLUL) Transferrin (TF) 21363012 -- -- Sulfotransferase fam.
Na segunda avaliacao, houve interacao genotipo x niveis de agua para altura de plantas (EST), numero de folhas vivas (NFV), comprimento de estolao primario (CES1), area foliar (AF), massa seca de folha (MSF), massa seca de estolao (MSE), numero de ramificacoes por estolao (ramif/est), condutancia estomatica (g), transpiracao (Tr) e numero de inflorescencias (NI).
Assay characteristics Assay S/B (a) S/N (a) Enzyme sEH 4.0 [+ or -] 0.1 38 [+ or -] 8 CES1 11 [+ or -] 3 19 [+ or -] 2 CES2 9.2 [+ or -] 0.9 106 [+ or -] 33 CES3 6.1 [+ or -] 0.7 28 [+ or -] 7 FAAH 150 [+ or -] 10 35 [+ or -] 5 P0N2 18 [+ or -] 2 134 [+ or -] 31 GSTs 2.4 [+ or -] 0.5 28 [+ or -] 9 CYP450 1A2 and 2C6 13 [+ or -] 5 48 [+ or -] 10 CYP450 2C9 19 [+ or -] 4 79 [+ or -] 18 Receptor AhR 32 [+ or -] 1 410 [+ or -] 30 ER 18 [+ or -] 2 180 [+ or -] 70 ER 5 [+ or -] 1 80 [+ or -] 40 RyR1 170 [+ or -] 30 500 [+ or -] 90 RyR2 100 [+ or -] 10 310 [+ or -] 40 Assay No.
Although both accession number X81395 and accession number U10697 were annotated as carboxylesterase 1 (Ces1) (presumably because of DNA sequence homology), the amino acid sequences are divergent enough to suggest that these are indeed two different proteins (data not shown).