FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
References in periodicals archive ?
As a rule of thumb, you should think of CEKs as usable only on "vanilla" columns or in "vanilla" code.
After being fielded, each CEK was sent to its geographic area of responsibility, and advise and assist teams were assigned to support them during their approximately 10-month training period.
Together, advisers and partners at all levels strive to provide functional advice to ANSF engineer leaders from the CEK to the Ministry of Defense.
Legal experts of BSP, however, counter that CEK has registered the GERB MPs as an initiative committee backing the "yes" position and now must take them out since currently they are proponents of the "no" one.
Xsilon is offering the HAN9000 CEK to vendors and service providers who are looking to deploy M2M services into the home environment, where existing communications technologies have failed to create a major footprint due to their poor connectivity within domestic premises.
Our cell line is able to remain free of unwanted pathogens, and above all, can out-live and outperform the only other tested cell line that registered any evident influenza virus levels, the CEK.
Since evidence was not presented with the claim, the magistrates requested evidence from CEK and local commissions.
Keith Cochrane, Interim CEO, Carillion, said: We are delighted that our Joint Venture, CEK, has been selected to deliver two of the three Central contracts for HS2 Phase 1, the London to Birmingham section of the route, reflecting the strength of our Joint Venture.
CEK has decided voting via electronic machines, as it is common practice in many western countries, is too expensive for Bulgaria, NEK member Mihail Konstantinov told bTV.
BBV JV (Balfour Beatty Group plc, Vinci Construction Grands Projets SAS, Vinci Construction UK Limited, Vinci Construction Terrassement SAS), CEK JV (Carrillion Construction Limited, Eiffage Travaux Publics, Kier Infrastructure and Overseas), Costain Skanska JV (Costain Limited, Skanska Construction Limited), LM (Laing ORourke, J.
Consequently, a Participation Group x Gender x Ethnicity x School Program x Grade ANOVA analyzed the CEKS gain scores.