APAF1

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APAF1

A gene on chromosome 12q23.1 that encodes a cytoplasmic protein, which initiates apoptosis. Apoptotic peptidase-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD) and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, APAF-1 forms an oligomeric apoptosome, which binds and cleaves caspase-9 preproprotein, releasing the activated form, which stimulates the caspase cascade that commits the cell to apoptosis.
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With respect to the molecular composition, we observed differences and a single profile for CE6, CEDp11, CEC12, and CES13, and we observed similarities between CEP1 and CEDp2, the samples CED3, CED4, and CEP5, and the samples CED7, CES8, and CE9.
[2] CED4 System Dynamics Group, University of Palermo, Palermo, Italy
* Correspondence to: Carmine Bianchi, CED4 System Dynamics Group, Via Mazzini, 59--90100 Palermo, Italy.