CEBPB


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Related to CEBPB: CEBPA, PubMed

CEBPB

A gene on chromosome 20q13.1 that encodes a transcription factor which binds as a homodimer to various DNA regulatory regions, and as a heterodimer to CEBP-beta, CEBP-delta and CEBP-gamma. CEBP-beta binds to regulatory regions—e.g., IL-1 response element in IL-6 gene—of genes involved in immune and inflammatory responses.
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Citation: "Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries"; Janus Schou Jakobsen et al.; Genome Research, advance online publication, DOI: 10.1101/gr.146399.112
Upregulation of the translation of ATF4 and other target proteins can then lead to increased transcription of stress-related genes (such as Atf3, Asns, Cebpb, and Trib3), allowing the cell to synthesize the subset of proteins needed to respond to the stress that initiated the response [10-12].
(307) French investigators demonstrated that nodal PTCL-NOS and ALCL could be distinguished at the molecular level (308) and found that BCL6, PTPN12, CEBPB, and SERPINA1 genes were differentially expressed in ALK+ ALCL, and CCR7, CNTFR, IL-22, and IL-21 in ALK- ALCL.
The MANI approach was implemented on time-series gene expression data obtained from a network of seven genes that belong to an adipogenesis regulatory network [11]: Kruppel Like Factor 4 (KLF4), CCAAT/Enhancer Binding Protein-alpha (CEBPa), CCAAT/Enhancer Binding Protein-beta (CEBPb), CCAAT/Enhancer Binding Protein-gamma (CEBPg), GLUcose Transporter type 4 (GLUT4), Xanthine Dehydrogenase (XDH), and Peroxisome Proliferator-Activated Receptorgamma (PPARg) (Figure 4(a)).