CDX2


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CDX2

A gene on chromosome 13q12.3 that encodes a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates its transcription. CDX regulates the transcription of multiple genes expressed in the intestinal epithelium, both during early differentiation and as part of the maintenance of the intestinal epithelial lining of the small and large intestines.

CDX2

A gut protein used clinically in immunocytochemistry to identify adenocarcinomas of the colon and other tissues and tumors of intestinal origin.
References in periodicals archive ?
NEW YORK, N.Y., May 20, 2019 -- Researchers here have demonstrated that stem cells derived from the placenta known as Cdx2 cells can regenerate healthy heart cells after heart attacks in animal models.
Cases With Discrepancies Between the 2 Cytopathologists Age, Classification Patient y/Sex CDx1 1 P13 40/F Negative for neoplasm II P14 63/F Lesion of unknown significance III P15 65/F Lesion of unknown significance III P46 85/F Suspicious for malignancy V Classification Patient CDx2 2 P13 Benign neoplasm IV P14 Benign neoplasm IV P15 Benign neoplasm IV P46 Positive for malignancy VI Patient HDx P13 Epidermal inclusion cyst P14 Granular cell tumor P15 Granular cell tumor P46 Low-grade malignant myoepithelioma Abbreviations: CDx, cytology diagnosis;HDx, histology diagnosis.
Researchers at the Icahn School of Medicine at Mount Sinai have demonstrated that stem cells derived from the placenta known as Cdx2 cells can regenerate healthy heart cells after heart attacks in animal models.
Summary: Washington D.C [U.S.A], May 22 (ANI): In a recent study, the researchers have found that stem cells generated from the placenta known as Cdx2 cells can regenerate healthy heart cells after heart failure as tested on animal models.
23 When there is a presence of metastatic NET with an unknown primary, then use of IHC staining panel with homeobox protein CDX2, pancreatic and duodenal homeobox 1 (PDX1), insulin gene enhancer protein ISL-1 and thyroid transcription factor 1 (TTF1) can aid in identification of the primary origin of metastatic NET.
Pathogenesis of Barrett esophagus: deoxycholic acid upregulates goblet-specific gene MUC2 in concert with CDX2 in human esophageal cells.
Immunohistochemical analysis revealed a panel indicative of intestinal epithelial histogenesis with immunoreactivity to CK20 and CDX2 markers.
The CDX2 nuclear transcription factor, which is an intestinal marker, may also be misleading because it also stains bladder adenocarcinomas.
El subtipo pancreatobiliar tipicamente muestra expresion CK7 y MUC1, mientras que el subtipo gastrico suele expresar MUC5AC y MUC6, el intestinal expresa MUC2, CDX2 y CK20, y el oncocitico, MUC1.
Endoscopic diagnosis of opentype atrophic gastritis is related to the histological diagnosis of intestinal metaplasia and Cdx2 expression.
The tumor cells were immunoreactive for CK7, CK19, CEA, and EMA but were nonimmunoreactive for CK20 and CDX2. A diagnosis of MA of the GB was made.
Uno de estos tipos de estudio, es el estudio por inmunohistoquimica, que, en el caso del adenocarcinoma del colon, utiliza con mas frecuencia los marcadores tumorales Citoqueratina 20 (KRT20), Citoqueratina 7 (KRT7) y el CDX2. [5,8].