CDX1

CDX1

A gene on chromosome 5q32 that encodes a DNA-binding protein belonging to caudal-related homeobox transcription factor gene family. The encoded protein regulates intestine-specific gene expression and enterocyte differentiation; it induces expression of the intestinal alkaline phosphatase gene, and inhibits beta-catenin/T-cell factor transcriptional activity.
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Cases With Discrepancies Between the 2 Cytopathologists Age, Classification Patient y/Sex CDx1 1 P13 40/F Negative for neoplasm II P14 63/F Lesion of unknown significance III P15 65/F Lesion of unknown significance III P46 85/F Suspicious for malignancy V Classification Patient CDx2 2 P13 Benign neoplasm IV P14 Benign neoplasm IV P15 Benign neoplasm IV P46 Positive for malignancy VI Patient HDx P13 Epidermal inclusion cyst P14 Granular cell tumor P15 Granular cell tumor P46 Low-grade malignant myoepithelioma Abbreviations: CDx, cytology diagnosis;HDx, histology diagnosis.
pylori infection induces the aberrant expression of the intestine-specific transcription factors CDX1 and CDX2.
Suzuki et al., "CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5," Proceedings of the National Academy of Sciences of the United States of America, vol.
The intestine-specific transcription factor caudal type homeobox-1 (CDX1) is downregulated with the treatment of hydrogen peroxide ([H.sub.2][O.sub.2]) because CDX1 promoter is hypermethylated and treatment with 5-aza-dC reversed this effect [68].
Other HOX genes, such as HOXB6, HOXB8, HOXC8, HOXC9, and CDX1 were also found to be dysregulated in human CRC development [67].
Hypoxia induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human endometrial cells.
CDX1 and CDX2 are aberrantly expressed in intestinal metaplasia.
WNT signalling pathway activation leads to the activation of CDX1, a downstream gene [283], which reprograms epithelial cells in mucosal lining to acquire stemness properties by inducing SALL4 and KLF5 factors [284].
Los inhibidores de GSK3 previenen la fosforilacion de [beta]-catenin, impidiendo su degradacion, resultando en traslocacion al nucleo para estimular la trascripcion de genes blanco, incluyendo c-JUN y homebox del gen CDX1 (63).
The cdx is selected from the cdx family and includes cdx1, cdx2, or cdx4.
Expression of CDX1 and VIL1 was relatively low in positive nodes compared with other markers, but the expression rates were 96- and 29-fold higher, respectively, than in benign nodes.
(22) Later, Nyquist et al (23) reported another novel fusion between the IRF2BP2 gene and the transcription factor CDX1 gene arising from the translocation through fluorescent in situ hybridization and whole-transcriptome sequencing analysis.