CDX1

CDX1

A gene on chromosome 5q32 that encodes a DNA-binding protein belonging to caudal-related homeobox transcription factor gene family. The encoded protein regulates intestine-specific gene expression and enterocyte differentiation; it induces expression of the intestinal alkaline phosphatase gene, and inhibits beta-catenin/T-cell factor transcriptional activity.
References in periodicals archive ?
Hypoxia induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human endometrial cells.
2012) CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.
Los inhibidores de GSK3 previenen la fosforilacion de [beta]-catenin, impidiendo su degradacion, resultando en traslocacion al nucleo para estimular la trascripcion de genes blanco, incluyendo c-JUN y homebox del gen CDX1 (63).
Expression of CDX1 and VIL1 was relatively low in positive nodes compared with other markers, but the expression rates were 96- and 29-fold higher, respectively, than in benign nodes.
These markers (CEA, CK19, CDX1, CK20, TACSTD1, and VIL1) are mostly epithelial-cell related markers that have absent or low expression in healthy LNs.
CDX1 is a member of the caudal-type homeobox family of genes.