CDT1 | definition of CDT1 by Medical dictionary
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CDT1 A gene on chromosome 16q24.3 that encodes a protein involved in forming the pre-replication complex required for DNA replication. CDT1 binding of geminin prevents replication, especially from initiating replication at inappropriate sites.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Bell, "Multiple Cdt1
molecules act at each origin to load replication-competent Mcm2-7 helicases," The EMBO Journal, vol.
The genes are called ORC1L, ORC4L and CDT1
, and are known to play a critical role in correct copying of DNA.
nominal rating is 1,500 psi, depending on bore size.