Cornelia de Lange syndrome

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de Lang·e syn·drome

(dĕ-lahng'ĕ),
a multiple congenital anomaly syndrome characterized by mental retardation, distinctive facies with microcephaly, synophrys, low anterior hairline, depressed nasal bridge, anteverted nares, long philtrum, carp mouth, thin upper lip and low-set ears, prenatal and postnatal growth retardation, hirsutism, and frequently, limb anomalies. Genetics unclear, although some instances appear to be autosomal dominantly inherited.

Cornelia de Lange syndrome

(kôr-nē′lē-ä də lăng′, də läng′, kôr-nā′lē-ä dĕ läng′ə)
n.
A congenital disorder characterized by intellectual disability, short stature, characteristic facies with thick eyebrows and low hairline, and limb abnormalities.

Cornelia de Lange syndrome

An often autosomal dominant, multiple congenital anomaly syndrome (OMIM:122470) characterised by mental retardation; distinctive facies with microcephaly, unibrow, low anterior hairline, depressed nasal bridge, anteverted nares, long philtrum, carp mouth, thin upper lip and low-set ears; prenatal and postnatal growth retardation; hirsutism; and frequently, limb anomalies.

de Lange,

Cornelia, Dutch pediatrician, 1871-1950.
Cornelia de Lange syndrome - Synonym(s): de Lange syndrome
de Lange syndrome - a congenital anomaly characterized by impaired development, mental retardation, characteristic facies with synophrys and hairline well down on forehead, depressed bridge of nose with uptilted tip of nose, small head with low-set ears, and flat spadelike hands with simian crease and short tapering fingers. Synonym(s): Amsterdam syndrome; Cornelia de Lange syndrome
References in periodicals archive ?
The ZIP policy is always optimal to the CDLS, if one of the following is true:
The non-ZIP (NZIP) policy is optimal to the CDLS, if one of the following is true:
Therefore, again unlike the Wagner-Whitin DLS, the ZIP policy is not always optimal to the CDLS.
For the situations where any of the ZIP properties in Theorem 1 and 3 is satisfied, we can obtain the optimal solution to the DDLS and CDLS by readily applying the Wagner-Whitin type dynamic programming (DP) recursion algorithm.
In order to illustrate a potential problem of blindly applying the Wagner-Whitin (WW) to the DDLS or CDLS situations, we compared total costs among the WW, the DDLS, and the CDLS approach, using the twelve-period demand data in Wagner and Whitin (1958).
And through examples, we illustrated a potential problem of blindly applying the WW approach to the DDLS and CDLS.
Cubic delivered its first production Navy CDLS system to SPAWAR in late May.
We are proud to unveil this early prototype of the CDLS to our Navy customers.
The CDLS is a "dual system" package that includes two antennas and two data link electronic for each ship, allowing naval commanders to track aircraft from any location aboard vessel.
The CDLS builds on Cubic's extensive experience in digital radios and data links.