CDKN2D

CDKN2D

A gene on chromosome 19p13 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 and CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2D inhibits neuronal proliferation, as well as spermatogenesis.
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3-q27 Change % of patients Candidate genes Loss 50-78 RB1 Loss 50-67 CDKN1B, ETV6 Loss 50-66 CDKN2A, CDKN2B, MTAP Loss 50-55 NOTCH, TRAF2, CARD9 Loss 21-44 SMAD5, MSH3, MCC, APC Loss 33-36 CYP1A1 Loss 29 PTPN23 Loss 22-29 CDKN2D, PRKCSH Loss 22 TP53 Loss 21 MAD1L1 Loss 11-21 PARK2 Table 3: Summary of the most frequent genomic alterations in BPDCN.
Overexpression of cyclin-dependent kinase inhibitor 1 (WAF1) from the kinase inhibitor protein group and PAK-[gamma] (p21- activated kinase [gamma]), combined with overexpression of CDKN2D (p19-INK4D) and cell division protein kinase 3 (CDK3), denote a major derangement in the regulation of cell-cycle progression.