CDK9


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CDK9

A gene on chromosome 9q34.1 that encodes a cyclin-dependent kinase, which regulates cell cycle progression. CDK9 is part of the multiprotein complex TAK/P-TEFb, an elongation factor for RNA polymerase II-directed transcription, which acts by phosphorylating the C-terminal domain of a subunit of RNA polymerase II. 

Molecular pathology
HIV-1 Tat protein interacts with CDK9 and cyclin T, suggesting CDK9 may have a role in AIDS.
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Tambien se ha observado que los niveles de CDK9 son similares entre los monocitos y los macrofagos (42); sin embargo, estos ultimos poseen mayor expresion de CDK9 fosforilada, que es importante para la activacion del P-TEFb (37).
CDK9, which has been implicated in the transcriptional regulation of genes involved in proliferation and inflammation, is said to be a promising target for the treatment of both cancer and inflammatory diseases.
Seliciclib is an orally-available cyclin dependent kinase (CDK) inhibitor that selectively inhibits multiple enzyme targets, CDK2/E, CDK2/A, CDK7 and CDK9, that are central to the process of cell division and cell cycle control.
According to the company firm, CDK9 has been involved in the transcriptional regulation of genes comprised in proliferation and inflammation and can target for the treatment of both cancer and inflammatory diseases.
In multiple myeloma, the addition of ERK5 inhibition and the established roles of the JAK-STAT and CDK9 pathways in myeloma cell survival and drug resistance suggest that TG02 could be an exciting addition to the armamentarium for this disease, added Dr Zaknoen.