CDK6


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CDK6

A gene on chromosome 7q21-q22 that encodes a cyclin-dependent kinase, which is a catalytic subunit of the protein kinase complex important in cell cycle G1-phase progression and G1/S transition. CDK6, with CDK4, phosphorylates and regulates the activity of tumour suppressor protein Rb.

Molecular pathology
CDK6 expression is upregulated in some cancers.
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References in periodicals archive ?
In this study, we reported for the first time that LIPUS promoted proliferation and migration of HaCaT cells, along with up-regulation of cyclinD1, CDK6, CDK4, VEGF, MMP-2, and MMP-9.
Low-intensity pulsed ultrasound promotes proliferation and migration of HaCaT keratinocytes through the PI3K/AKT and JNK pathways
The CCNDI protein is a major regulator in the cell cycle's Gl-S checkpoint, and it has an important role in cell cycle arrest, tumor suppressor inhibition, or oncogene activation because it is related to CDK4 and CDK6 [21].
Investigation of the Anticancer Mechanism of isoorientin isolated from Eremurus SpectabHis Leaves via Cell Cycle Pathways in HT-29 Human Colorectal Adenocarcinoma Cells
Pavletich, "Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16(INK4a)," Nature, vol.
Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
We found that the expression of both the cell death (Bad and Bax) and cell proliferation (Ccnd1, Cdk6, and Sox4) genes was significantly increased in the organoids and intestine of [Lep.sup.ob/ob] mice compared to normal (Figures 2(d), 2(e), 2(g), and 2(h)).
Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet
studied the role of CDK6, but he noticed that CDK6 expression in OLP did not differ from normal mucosa, an observation which suggests that CDK6 is not significantly involved in OLP pathogenesis [74].
Markers of Oral Lichen Planus Malignant Transformation
The company said Verzenio (abemaciclib) is an inhibitor of CDK4 and CDK6, which are activated by binding to D-cyclins.
Eli Lilly and Company awarded US FDA's priority review for verzenio (abemaciclib) for advanced breast cancer
Eli Lilly and Company today announced that its Phase 3 JUNIPER study evaluating Verzenio (abemaciclib), a cyclin-dependent kinase (CDK)4 and CDK6 inhibitor, as monotherapy in KRAS-mutated, advanced non-small lung cancer (NSCLC) did not meet its primary endpoint of overall survival (OS).
United States : Lilly Reports Topline Results from Phase 3 JUNIPER Trial Evaluating Verzenio (abemaciclib) in KRAS-Mutated, Advanced Non-Small Cell Lung Cancer
Cyclin D1 achieves this effect by binding to cyclin dependent kinases (CDK) 4 and CDK6 forming a CDK/cyclin complex able to phosphorylate the retinoblastoma (RB1) gene- with subsequent release of the E2F transcription factor activating essential genes needed for S phase entry [13].
Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma
On the other hand, miR449 directly affects E2F inducer Cdk6 and CycE, thus forming negative feedbackloops [12,14].
Bifurcations and Dynamics of the Rb-E2F Pathway Involving miR449
In contrast, miR-200a-3p upregulation suppresses gene inhibitors for EED and EZH2 (KIF20A and HSD17B11 for EED and CDK6 for EZH2) and allows these two transcription factors to positively affect the transcription of interferons IFNA1 and IFNA2.
Dysregulation of miR-155-5p and miR-200-3p and the Anti-Non-Bilayer Phospholipid Arrangement Antibodies Favor the Development of Lupus in Three Novel Murine Lupus Models
ID miRNA Sequence MIMAT0000104 hsa-miR-107 50-agcagcauuguacagggcuauca-72 MIMAT0000765 hsa-miR-335-5p 16-ucaagagcaauaacgaaaaaugu-38 MIMAT0000083 hsa-miR-26b-5p 12-uucaaguaauucaggauaggu-32 ID Target MIMAT0000104 PLAG1, BACE1, CDK6, GRN, DAPK 1, PTEN, NOTCH 2, NFIA, SERBP1 MIMAT0000765 TNC, RASA1, IGFR1, SP1, APBB2 MIMAT0000083 SLC17A6, (DNP1/vGLUT2) Note.
Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's Disease
found CCND1, CDK2, and CDK6 directly targeted by miR-186 in lung adenocarcinoma [27].
MiR-195 Inhibits Tumor Growth and Metastasis in Papillary Thyroid Carcinoma Cell Lines by Targeting CCND1 and FGF2

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