CDK5


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CDK5

A gene on chromosome 7q36 that encodes a kinase that is involved in controlling the cell cycle by interacting with D1- and D3-type G1 cyclins.
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Therefore, it can be concluded that GSK-3b may act as a downstream protein of CDK5 in the signaling pathways for AD occurrence, and the association of HIg with Ab inhibits the cleavage of P35 to P25 and disrupts the activities of both CDK5 and GSK-3b, thus decreasing the occurrence of neurofibrillar tangles and the death rates of nerve cells and improving the survival rates of cells.
The CDK5 and MAP kinases together form important signaling systems.
In this regard it is of importance to note the reported role of CDK5 and ERK1/2 during development, cell differentiation and regeneration following degeneration.
cerevisiae); PPARG, peroxisome proliferator--activated receptor gamma; AKT2, v-akt murine thymoma viral oncogene homolog 2; INSR, insulin receptor; SLC30A8, solute carrier family 30 (zinc transporter), member 8; HHEX, hematopoietically expressed homeobox; CDKAL1, CDK5 regulatory subunit associated protein 1-like 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); IGF2BP2, insulin-like growth factor 2 mRNA binding protein 2; FTO, fat mass and obesity associated; JAZF1, JAZF zinc finger 1; CDC123, cell division cycle 123 homolog (S.
b) Human genes: PPARG, peroxisome proliferator-activated receptor gamma; SLC30A8, solute carrier family 30 (zinc transporter), member 8; HHEX, hematopoietically expressed homeobox; CDKAL1, CDK5 regulatory subunit associated protein 1-like 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); IGF2BP2, insulin-like growth factor 2 mRNA binding protein 2; FTO, fat mass and obesity associated; HNF1B, HNF1 homeobox B; WFS1, Wolfram syndrome 1 (wolframin); JAZF1, JAZF zinc finger 1; CDC123, cell division cycle 123 homolog (S.
CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) was independently identified as anew T2D locus in all 4 studies.
In addition, a locus strongly associated with type 2 diabetes, CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), has clearly been shown to operate through birth weight (31, 32).
5] Human genes: FTO, fat mass and obesity associated; CDKAL1, CDK5 regulatory subunit associated protein 1-like 1.