CDK4 gene | definition of CDK4 gene by Medical dictionary
cyclin-dependent kinase (redirected from CDK4 gene)
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cyclin-dependent kinase Abbreviation: CDK
A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.
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References in periodicals archive
For example, we know a faulty CDKN2A and CDK4 gene
indicates that you're at greater risk for melanoma.
Burrows does not recommend testing for the CDKN2A and CDK4 gene
mutations in most patients.
The cdk4 gene
is localized to human chromosome segment 12q13-14, which also contains mdm2.
The MDM2 and CDK4 genes
are located on chromosome 12 in close proximity to one-another, with CDK4 very frequently co-amplified in the MDM2-amplification-positive patients to be enrolled in this trial.