cyclin-dependent kinase

(redirected from CDK4 gene)
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cyclin-dependent kinase (CDK)

a protein kinase that is activated by cyclin.

cyclin-dependent kinase

Abbreviation: CDK

A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.

See also: kinase

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References in periodicals archive ?

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

Altered expression of G1 regulatory proteins in human soft tissue sarcomas. (Original Articles)

Dracopoli is a widely published expert in human genetics and discovered the genetic predisposition to melanoma associated with the CDK4 gene.

Bristol-Myers Squibb to Pioneer Personalized Medicines for Cancer Patients

Therefore, researchers in the current study searched for alterations in the CDK4 gene, reasoning that normal cell division could be affected just as easily by an alteration in CDK4 as in p16.