cyclin-dependent kinase

(redirected from CDK4 gene)
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cyclin-dependent kinase (CDK)

a protein kinase that is activated by cyclin.

cyclin-dependent kinase

Abbreviation: CDK

A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.

See also: kinase

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References in periodicals archive ?

The cdk4 gene is localized to human chromosome segment 12q13-14, which also contains mdm2.

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

Altered expression of G1 regulatory proteins in human soft tissue sarcomas. (Original Articles)

Therefore, researchers in the current study searched for alterations in the CDK4 gene, reasoning that normal cell division could be affected just as easily by an alteration in CDK4 as in p16.