cyclin-dependent kinase

(redirected from CDK4 gene)
Also found in: Encyclopedia.

cyclin-dependent kinase

Abbreviation: CDK

A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.

See also: kinase

Mentioned in ?

References in periodicals archive ?

For example, we know a faulty CDKN2A and CDK4 gene indicates that you're at greater risk for melanoma.

Personalize your cancer treatment

Burrows does not recommend testing for the CDKN2A and CDK4 gene mutations in most patients.

Multiple melanomas a real phenomenon

The cdk4 gene is localized to human chromosome segment 12q13-14, which also contains mdm2.

Altered expression of G1 regulatory proteins in human soft tissue sarcomas. (Original Articles)

The MDM2 and CDK4 genes are located on chromosome 12 in close proximity to one-another, with CDK4 very frequently co-amplified in the MDM2-amplification-positive patients to be enrolled in this trial.