CDK3


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CDK3

A gene on chromosome 17q22-qter that encodes a cyclin-dependent protein kinase, which promotes entry into S phase in part by activating E2F family transcription factors. CDK3 associates with cyclin C and phosphorylates retinoblastoma 1 protein to promote exit from G0.
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Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
Table 2: The CDK3 RFLP--Interpretation Sl No Sample ID Bands detected (bp) Results 1 SD3 166r 209 bp and 99 bp Homozygous Recessive 2 SD2 157r 209 bp and 99 bp Homozygous Recessive 3 SD3 294r 308 bp, 209 bp and 99 bp Heterozygous 4 SD4304r N/A 5 SD2166r 209 bp and 99 bp Homozygous Recessive 6 SD2 274r 209 bp and 99 bp Homozygous Recessive 7 SD2 56r 209 bp and 99 bp Homozygous Recessive 8 SD1 185r 308 bp, 209 bp and 99 bp Heterozygous 9 SD1119r 308 bp, 209 bp and 99 bp Heterozygous 10 SD2 226r 308 bp, 209 bp and 99 bp Heterozygous
Estimation of homozygote recessive and heterozygous CDK3 distribution in randomly selected cancer subjects

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