CDK2


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CDK2

A gene on chromosome 12q13 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is essential for G1/S phase transition in the cell cycle. CDK2 associates with, and is regulated by, the regulatory subunits of the complex (cyclin A or E), CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B); its activity is regulated by phosphorylation.
References in periodicals archive ?
Kanget al., "Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells," Molecular Cancer Therapeutics, vol.
Morgan, "Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15," EMBO Journal, vol.
(a) Whole cell lysates after PEMF treatment of hBMSCs of a 24-year-old female at day 23 (differentiation) and (b) at day 33 (mineralization) were subjected to Western blot analysis using the antibodies as indicated for Smad2 and Cdk2. TGF-[beta]2 (5 ng/mL) was added to control (non-PEMF-treated) cells on days 23 and 33 as positive controls.
Cyclin A, cyclin B1, cyclin-dependent kinase (CDK) 1, and CDK2 are four critical regulators at G2/M checkpoint responsible for driving cells into the mitosis process [12].
Oishi et al., "CDK1 and CDK2 activity is a strong predictor of renal cell carcinoma recurrence," Urologic Oncology: Seminars and Original Investigations, vol.
For HGSOvCa, we found that irinotecan and STAT3 inhibitors may be candidates for the immunoreactive subtype, along with bortezomib, CDK2, XPO1 inhibitors, and vincristine for the proliferative subtype and integrin signaling inhibitors for the mesenchymal subtype.
Amygdalin blocks bladder cancer cell growth in vitro by diminishing cyclin A and cdk2. PLoS ONE.
Furthermore, the transitions between late G1, and G1-S and G2/M cell cycle phases are regulated by cyclins A/E in conjunction with their catalytic partners CDK2 through their nuclear translocation to control cell cycle progression, DNA synthesis and mitosis [50].
Since metastatic cells that were beginning to differentiate into secondary tumors showed high expression of genes cMYC and CDK2, the researchers treated 24 PDX mice with dinaciclib, a CDK inhibiting drug known to kill off cells with high MYC levels.
A third RNA sample (50 ng/[micro]L) was reverse-transcribed by Readyscript and subjected to dualplex CDK2 (cyclin-dependent kinase 2)/RBL1 (retinoblastoma-like 1) or MAX MYC (v-myc avian myelocytomatosis viral oncogene homolog) and singleplex UBC (ubiquitin C) #1 qPCR analysis.
Roscovitine, while being able to inhibit other cdks such as Cdk2 (IC50 of 0.7 [micro]M) and Cdc2 (IC50 of 0.65 [micro]M), has a high affinity for Cdk5 (IC50 of 0.16 [micro]M) [47].
Furthermore, edible berries like raspberry, gooseberry, black currant and low bush berry contain bioactive photochemical compounds such as phenolic acid, proanthrocyanidins, anthocyanin and other flavonoids that offer protection from breast cancer by arresting the cell cycle.1 These compounds down regulate the expressions of cdK2, cdK4, cyclin D1, cyclin D3, inhibit Tumour Necrosis Factor (TNF) induce COX-2 expression and activate the transcription factor NFKB.2 The former effects of berries are those that have been proven to prevent the cancer if down regulated, inhibited, induced and activated respectively.