The hub genes included PDS5 cohesin associated factor B (PDS5B), chromodomain helicase DNA binding protein 5 (CHD5), cyclin-dependent kinase 17 (CDK17), eukaryotic translation initiation factor 3 subunit E (EIF3E), ATPase H+ transporting V1 subunit H (ATP6V1H), G protein subunit alpha 13 (GNA13), PHD finger protein 21A (PHF21A), methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (MTHFD2), lipoprotein lipase (LPL), adenylosuccinate synthase (ADSS), Wnt family member 10B (WNT10B), and serine and argininerich splicing factor 1 (SRSF1).
According to the analysis, we found that only the downregulation of CDK17, GNA13, PHF21A, and MTHFD2 was closely associated with a decreased overall survival among patients with glioma (Figures 3 and 4).
Survival analysis found that CDK17, GNA13, PHF21A, and MTHFD2 are closely associated with glioma.
According to the study, downregulation of CDK17, GNA13, PHF21A, and MTHFD2 can be considered as biomarkers or therapeutic targets for glioma.