CDK1


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CDK1

A gene on chromosome 10q21.1 that encodes a Ser/Thr protein kinase family, a catalytic subunit of the conserved complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins associate with CDK1, controlling its activity by cyclin accumulation and destruction through the cell cycle; phosphorylation and dephosphorylation of CDK1 play important regulatory roles in controlling the cell cycle.
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Of these 15 hub genes, PHLPP2, DLG4, and MYC displayed significant positive correlation with overall survival while TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1 negatively correlated with overall survival in patients with glioma.
Identification of Core Biomarkers Associated with Outcome in Glioma: Evidence from Bioinformatics Analysis
DATS decreased the expression of cyclin B1 and CDK1, while cyclin A and CDK2 were not apparently affected by DATS (Figure 2(c)).
Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide
Expression Levels of Bcl-2, Cdk1, and p53 in MCF-7 and MDA-MB-231 Cells.
Cytotoxicity and Proapoptotic Effects of Allium atroviolaceum Flower Extract by Modulating Cell Cycle Arrest and Caspase-Dependent and p53-Independent Pathway in Breast Cancer Cell Lines
They found that after its levels peaked during the day, two proteins, CDK1 and FBXW7, interacted with REV-ERBα to help reduce its levels to a low point by the middle of the night.
How Your Circadian Rhythm Gets Powered Up
MicroRNAs Expression Mechanism of function Cancer References miR-16 Decreased Inhibits prostate tumor PCa [61] growth through regulation of genes expression such as CDK1 and CDK2 miR-141 Increased Its serum level is PCa [62] increased in patients with bone metastatic Pca and is related to bone metastatic lesion.
Molecular regulation of bone marrow metastasis in prostate and breast cancer
Expression levels of cyclins (cyclins A1, A2, B1, B2, D1, D2, and F), CDKs (CDK1 and CDK2), and E2Fs (E2F1 and E2F2) increase, whereas cell cycle inhibitors (Cdkn1a and Cdkn2a) decrease in islets of betatrophin-injected mice compared to control-injected mice.
Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions
Furthermore, expression of cyclin-dependent kinases (Cdk4, Cdk6, and Cdk1) was also significantly higher than in the control in almost every day of regeneration.
Enucleation-induced rat adrenal gland regeneration: expression profile of selected genes involved in control of adrenocortical cell proliferation
For example, TSA and sodium butyrate (NaB) treatment cause reductions in the mRNA levels of the cdk1 gene (Saunders et al., 1999).
Effects of trichostatin A on cumulus expansion during mouse oocyte maturation
Alternatively, MPF apparently involves phosphorylation changes in MPF's kinase moiety (=Cdc2 or Cdk1), as maturing oocytes exhibit both decreased inhibitory phosphorylation at the Y15 site of Cdc2 and increased stimulatory phosphorylation at T161 on Cdc2 (Stricker and Smythe, 2003, 2006a) (Fig.
Oocyte maturation and fertilization in marine nemertean worms: using similar sorts of signaling pathways as in mammals, but often with differing results
SIRT1 is phosphorylated by cyclin B/cell cycle dependent kinase (Cdk1), and this process regulates its deacetylase activity which in turn affects cell proliferation.
SIRT1: Importance of O-GlcNAc and Phosphorylation Interplay in Aging and Diabetes
The resulting cDNA was subjected to SYBR green real-time PCR to investigate the differential expression of PLK1 interacting genes including AURKA, PSMB5, MDM2, PKMYT, CHUK, and CDK1. The primer sequences used for these genes are summarized in Table 1.
Polo-like kinase 1: a novel target for the treatment of therapy-resistant mantle cell lymphoma
CHK2 phosphorylation on T68 and the high expression of cell cycle regulators, Cyclin E, Cyclin D, and CDK1, are characteristics of these tumors [19].
The estrogen receptor joins other cancer biomarkers as a predictor of outcome

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