CDK1


Also found in: Acronyms.

CDK1

A gene on chromosome 10q21.1 that encodes a Ser/Thr protein kinase family, a catalytic subunit of the conserved complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins associate with CDK1, controlling its activity by cyclin accumulation and destruction through the cell cycle; phosphorylation and dephosphorylation of CDK1 play important regulatory roles in controlling the cell cycle.
Mentioned in ?
References in periodicals archive ?
Of these 15 hub genes, PHLPP2, DLG4, and MYC displayed significant positive correlation with overall survival while TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1 negatively correlated with overall survival in patients with glioma.
DATS decreased the expression of cyclin B1 and CDK1, while cyclin A and CDK2 were not apparently affected by DATS (Figure 2(c)).
They found that after its levels peaked during the day, two proteins, CDK1 and FBXW7, interacted with REV-ERBα to help reduce its levels to a low point by the middle of the night.
MicroRNAs Expression Mechanism of function Cancer References miR-16 Decreased Inhibits prostate tumor PCa [61] growth through regulation of genes expression such as CDK1 and CDK2 miR-141 Increased Its serum level is PCa [62] increased in patients with bone metastatic Pca and is related to bone metastatic lesion.
Expression levels of cyclins (cyclins A1, A2, B1, B2, D1, D2, and F), CDKs (CDK1 and CDK2), and E2Fs (E2F1 and E2F2) increase, whereas cell cycle inhibitors (Cdkn1a and Cdkn2a) decrease in islets of betatrophin-injected mice compared to control-injected mice.
Furthermore, expression of cyclin-dependent kinases (Cdk4, Cdk6, and Cdk1) was also significantly higher than in the control in almost every day of regeneration.
For example, TSA and sodium butyrate (NaB) treatment cause reductions in the mRNA levels of the cdk1 gene (Saunders et al., 1999).
Alternatively, MPF apparently involves phosphorylation changes in MPF's kinase moiety (=Cdc2 or Cdk1), as maturing oocytes exhibit both decreased inhibitory phosphorylation at the Y15 site of Cdc2 and increased stimulatory phosphorylation at T161 on Cdc2 (Stricker and Smythe, 2003, 2006a) (Fig.
SIRT1 is phosphorylated by cyclin B/cell cycle dependent kinase (Cdk1), and this process regulates its deacetylase activity which in turn affects cell proliferation.
The resulting cDNA was subjected to SYBR green real-time PCR to investigate the differential expression of PLK1 interacting genes including AURKA, PSMB5, MDM2, PKMYT, CHUK, and CDK1. The primer sequences used for these genes are summarized in Table 1.
CHK2 phosphorylation on T68 and the high expression of cell cycle regulators, Cyclin E, Cyclin D, and CDK1, are characteristics of these tumors [19].