CDKN2B

(redirected from CDK inhibitory protein)

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
References in periodicals archive ?
The presence of specific CDK inhibitory proteins regulates the activities of cyclins and CDKs.
Proteins termed CDK inhibitory proteins including INK4 proteins and the Kip/Cip proteins can also bind to cyclin-Cdk complexes.
The kinase activity of cdks is regulated by the abundance of their partner cyclins, phosphorylation and dephosphorylation events, and interaction with cdk inhibitory proteins (p15, pl6, p21, p27 and p57).