CDK


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kinase

(kin'as)
An enzyme that catalyzes the conversion of a proenzyme to a fully active enzyme.

cyclin-dependent kinase

Abbreviation: CDK
A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.

myosin light chain kinase

An enzyme in smooth muscle cells that catalyzes the transfer of a phosphate group from adenosine triphosphate to myosin, which initiates contraction.

protein kinase

See: protein kinase

tyrosine kinase

Any of a group of enzymes that influence signaling between cells, esp. as relates to cell growth and death, cellular adhesion and movement, and cellular differentiation. Abnormalities in tyrosine kinases are found in some human diseases, including chronic myeloid (myelogenous) leukemia.

cyclin-dependent kinase

Abbreviation: CDK
A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.
See also: kinase
References in periodicals archive ?
Though he observed that in many cases many citizens owned companies were termed failures and characterised as incompetent, CDK delivered a massive project to silence the critics.
This year, PCG recognized CDK Global with two awards for their Enterprise Class websites and Digital Advertising platform, said Brian Pasch, founder PCG Companies.
The CDK Partner Program now numbers more than 350 partner companies and 450 unique applications auto dealers can use to run their businesses.
Chemical substructure types Dimensions CDK 1024 CDKExt 1012 FP4 131 Graph 1023 KR 1834 MACCS 153 PubChem 627 Table 3: The performance of 10-fold cross validation on 5 datasets.
In determining that, they have looked deeper into the genetic switches that turn malignancies on and off, giving them new insight in how the CDK inhibitors block growth in different cell types.
Short for corrected Dall-Kirkham, the CDK traces its roots to a 1990s telescope-making class at El Camino College in Torrance, California.
Patient Screening--The ability to screen potential CDK patients varied across clinics but was generally limited by weak referral patterns in nonintegrated health systems and limited programs was cited as a factor in increasing early-stage referrals.
Both Cdc25 phosphatases seem to function as key regulators of the G1-S and G2-M transitions and of mitosis, to spatially and temporally regulate their respective CDK substrates.
One group of these novel compounds works by inhibiting Cyclin Dependent Kinases (CDK), drug targets that control cancer cell division.
Cyclacel Limited, the UK-based biopharmaceutical company, has demonstrated through state-of-the-art biomarker technology that CYC202 (R-roscovitine), its lead CDK inhibitor drug candidate, appears to induce cancer cell suicide or apoptosis in patients receiving the drug.
This gene encodes a protein called cyclin dependent kinase 1, or CDK 1.