In neurons, psychopathy was associated with marked upregulation of RPL10P9 and ZNF132, and downregulation of CDH5
The expression level of endothelial/hematoendothelial markers (CD34, CDH5
, KDR, and CD31) and hematopoietic TFs (Bmi1, Etv6, Lmo2, ERG, SCL, Gata2, CMYB, etc.) was low in most of group A (Figure 2D).
The top five CpG sites met a predefined FDR cutoff of <0.05 and were found in the following genes: cadherin-like 22 (CDH22), family with sequence similarity 19 (chemokine- (C-C motif-) like), member A2 (FAM19A2), cadherin-like 22 (CDH5
), casein kinase 1 (CSNK1E), and Delta/notch-like EGF repeat (DNER).
Classical cadherins can be further subdivided into the type I classical cadherins consisting of CDH1 (E-cad), CDH2 (N-cad), CDH3 (P-cad), CDH4 (R-cad), and CDH15 (M-cad); the type II classical cadherins include CDH5
(VE-cad), CDH6 (K-cad), CDH7, CDH8, CDH9 (T1-cad), CDH10 (T2-cad), CDH11 (OB-cad), CDH12 (N-cad-2), CDH18, CDH19, CDH20, CDH22, and CDH24.
Four Epac1 floxed and Epac1 Cdh5
Cre-lox mice were euthanized with carbon dioxide and cervical dislocation.
(15) Cadherin-5 (CDH5
) is an endothelial specific adhesion molecule and major component of endothelial adherins junctions.
Three of these six genes had higher expression in biopaper cocultures, including gamma-glutamyltransferase 5 (GGT5, p = 0.002), tight junction protein 2 (TJP2, p < 0.001), and cadherin-5 (CDH5
, p = 0.02).
ANGPT1, TIE2, PDGFR-B, CDH5
, S1PR1, FGF2, Shh, and TGFRB1), and blood vessel maturation/formation factor (e.g.
Other genetic studies of keratocystic odontogenic tumors have detected deletions within cadherin-related genes (CDH5
and CDH18), possibly providing an explanation for the frequently observed detachment of the cyst-lining epithelium from the under lying stroma, a histopathologic hallmark of these lesions (Figure 2).
Two upregulated genes (CASP4 and ARL6IP) are at loci reported by other investigators to have gained chromosomal material in gastric tumors while six downregulated genes (SYNPO2, COX7C, SNAPC3, CDH5
, DHX33, and CNN1) had chromosomal loss.
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5
(VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).