CDH4

CDH4

A gene on chromosome 20q13.3 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH4 is thought to play a key role in brain segmentation and neuronal outgrowth, as well as in kidney, muscle and retinal development .
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Classical cadherins can be further subdivided into the type I classical cadherins consisting of CDH1 (E-cad), CDH2 (N-cad), CDH3 (P-cad), CDH4 (R-cad), and CDH15 (M-cad); the type II classical cadherins include CDH5 (VE-cad), CDH6 (K-cad), CDH7, CDH8, CDH9 (T1-cad), CDH10 (T2-cad), CDH11 (OB-cad), CDH12 (N-cad-2), CDH18, CDH19, CDH20, CDH22, and CDH24.
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).
To investigate the status of CDHs in breast cancer, we screened 27 members of CDHs in TCGA datasets and found that CDH1 was indeed low expressed or mutated in 16% of TCGA samples, and other CDHs (especially CDH17, CDH4, CDH26, CDH3/8, and CDH2/6/12) were almost highly expressed or amplified (Supplementary Figure S1 in Supplementary Material at https://doi.org/10.1155/2017/5091541).
Other target genes encode proteins such as MADCAM1 (mucosal vascular addressin cell adhesion molecule 1), MARCKSL1 (macrophage myristoylated alanine-rich C kinase substrate-like 1), and CDH4 (cadherin 4), which are associated with cell adhesion and migration, a process known to be regulated by MNRR1 [29] and LACTB (lactamase beta), which forms filaments in the mitochondrial IMS and is part of a network of genes that were validated to have a casual association with obesity traits [85].
ORE Genes containing ORE up to 1000 bp upstream of the gene MNRR1 LOC105370119, MIR661, MNRR1, ST18, MADCAM1, (5-TGTCCCACGTCCGGA-3) RBBP8NL COX4I2 ADPRHL1, ADRA2A, C18orf8, C2CD2, CASZ1, CDH4, (5-TTCCCACGCTGGGG-3) CNPY4, COX4I2, EEF1DP3, ESYT1, FBP1, KIAA1614, LACTB, LINC00403, MAP2K5, MARCKSL1, MIR36481, NOL9, RNF150, SDHAF1, USP28, WWC1
Revolution Analytics has increased support for Hadoop as a platform for Big Data analytics with Cloudera CDH3 and CDH4 in its upcoming release of Revolution R Enterprise 7.0.
Revolution R Enterprise 6.2, currently available, is certified to work with Cloudera CDH3 and CDH4, allowing researchers to write their own Hadoop-based analytics in R and deploy them within the Cloudera environment.
Along with CDH4, customers can buy this solution with Dell 12th generation PowerEdge servers including the R720, R720XD, or PowerEdge C servers; PowerConnect or Force10 switches; services from Dell and Canonical.