CDH3

CDH3

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH3 is also a retired HUGO symbol for what is now designated CDH15, see there.

Molecular pathology
Loss of heterozygosity mutations of CDH3 occur in breast and prostate cancer; aberrant expression of cadherin 3 occurs in cervical adenocarcinomas. CDH3 mutation causes congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia with ectrodactyly and macular dystrophy.
References in periodicals archive ?
Classical cadherins can be further subdivided into the type I classical cadherins consisting of CDH1 (E-cad), CDH2 (N-cad), CDH3 (P-cad), CDH4 (R-cad), and CDH15 (M-cad); the type II classical cadherins include CDH5 (VE-cad), CDH6 (K-cad), CDH7, CDH8, CDH9 (T1-cad), CDH10 (T2-cad), CDH11 (OB-cad), CDH12 (N-cad-2), CDH18, CDH19, CDH20, CDH22, and CDH24.
There are 8 out of 10 downregulated DEGs that are downregulated in Group II compared with those in Group I, namely VIPR1, SLC6A4, NECAB1, LEPREL1, ITLN2, HSD17B6, HHIP, and CRTAC1 and 14 out of 57 upregulated DEGs that are upregulated in Group II compared with those in Group I, namely TRIM2, TP63, TMPRSS4, SPP1, SIX4, MMP1, ITGB8, GOLM1, CP, COL17A1, CLIC6, CDH3, CD24, and C12orf75.
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).
Por su parte, la cadherina P es una glucoproteina codificada por el gen CDH3, localizado tambien en el cromosoma 16q22.1.
Mellanox has been certified on all previous versions of Cloudera solutions, including CDH3 and CDH4, so customers can securely deploy their choice of data intensive applications delivering performance, resiliency and cost effectiveness, using Mellanox interconnect solutions.
These overlapping genes are ABCG2, AQP8, CA1, CA4, CA7, CD177, CDH3, CLCA4, CLDN8, EDN3, FCGBP, GCG, GUCA2A, GUCA2B, KIAA1199, MMP7, MS4A12, MT1M, MUC2, PYY, SLC26A3, SLC4A4, SPIB, SST, and ZG16.
Revolution Analytics has increased support for Hadoop as a platform for Big Data analytics with Cloudera CDH3 and CDH4 in its upcoming release of Revolution R Enterprise 7.0.
Revolution R Enterprise 6.2, currently available, is certified to work with Cloudera CDH3 and CDH4, allowing researchers to write their own Hadoop-based analytics in R and deploy them within the Cloudera environment.
(74) Eleven genes--COL1A2, COL6A1 (collagen), tPA, MMP9 (protease), CDH3, L1CAM, ITGB4, PLXNA3/PLXN3, KRT14/K14 (cell adhesion or cell surface molecule), SEMA3C (semaphorin), and CXCL10/INP10 (chemokine)--were overexpressed in MPM.
Apache Hadoop-based data management software and services provider Cloudera announced on Wednesday that unstructured data analytics provider Digital Reasoning has integrated its Distribution including Apache Hadoop (CDH3) along with support of HBase open-source, column-oriented store into the upcoming Version 3.1 release of Synthesys.
Four genes namely LAMB1, CDH1, CDH3 and HNF4A play vital roles in keeping the intestine lining healthy.