CDH2

CDH2

A gene on chromosome 18q11.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH2 functions during gastrulation and is required for establishing left-right asymmetry. At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by CDH2; in the hippocampus, it may regulate dendritic spine density.
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Previous study suggested that many genes and signalling pathway are involved in early pregnancy, and some genes are essential for maintaining pregnancy, and the miscarriage was triggered by the dysfunction of these genes, such as cadherin 2 (CDH2), which is a gene of cell adhesion molecules (CAMs) [5]; collagen type VI alpha 3 chain (COL6A3), thrombospondin 1 (THBS1), fibronectin 1, integrin beta 4 (ITGB4) [6], which are all PI3KAkt signaling pathway genes; matrix metallopeptidase 14 (MMP14), vascular cell adhesion molecule 1 (VCAM1) [7], matrix metallopeptidase 9 (MMP9), which are all tumor necrosis factor (TNF) signaling pathway genes; additionally, MAPK signaling pathway [8] and Hippo signaling pathway [9] are involved in maintaining pregnancy.
After the treatment with gemcitabine or combination of FA and gemcitabine, the expression levels of important genes associated with metastasis including MMP-2, MMP-9, TIMP-1, TIMP-2, CDH1, CDH2, COL4A2, VEGF and HIF1A were determined using qPCR analysis.
We first developed and analytically validated 3 multiplex RT-qPCR assays for the quantitative determination of (a) Epithelial markers: CK-19 (KRT19), EpCAM, E-cadherin (CDH1), and HMBS (reference gene); (b) Stem cell markers: PSCA, ALDH1A1, CD133 (PROM1), and HPRT1 (reference gene); and (c) EMT markers: TWIST1, Vimentin (VIM), N-cadherin (CDH2), and B2M (reference gene).
Huang et al., "Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells," Stem Cell Research, vol.
Classical cadherins can be further subdivided into the type I classical cadherins consisting of CDH1 (E-cad), CDH2 (N-cad), CDH3 (P-cad), CDH4 (R-cad), and CDH15 (M-cad); the type II classical cadherins include CDH5 (VE-cad), CDH6 (K-cad), CDH7, CDH8, CDH9 (T1-cad), CDH10 (T2-cad), CDH11 (OB-cad), CDH12 (N-cad-2), CDH18, CDH19, CDH20, CDH22, and CDH24.
The more than 1000-fold expression difference between epithelial (E-cadherin, CDH1, low) and neuronal cadherin (N-cadherin, CDH2, high) indicated that the NCCs had undergone epithelial-to-mesenchymal transition (Nieto, 2011) and thus have a high migratory capacity.
As shown in Supplementary Table 1, there are several dysregulated transcripts associated with age (ITLN2, BTNL9, TNC, TDO2, SPP1, PSD3, and LTBP1); gender (SLC6A4, HSD17B6, CRTAC1, TNC, TDO2, SPP1, and LRRC17); and smoking (CFH, CDH2).
Next-generation sequencing (NGS) studies revealed numerous genetic alterations including 6 pathogenic mutations in ASXL1, BCOR, CDKN2A, NF1, and TP53(x2) genes and 30 variants of unknown significance (VOUSs) in ABL1, ASXL1, ATM, BCOR, BCORL1, BRNIP3, CDH2, CDKN2A, DNMT3A, ETV6, EZH2, FBXW7, KIT, NF1, RUNX1, SETPB1, SF1, SMC1A, STAG2, TET2, TP53, and U2AF2 (Table 1).
Net earnings attributable to common shareholders were CDH2,136 million or CDN3.00 per share, compared with CDN1,896 million or CDN2.67 per share in 2013.
We determined the expression of rat Apc, Espn (espin), Cdh2 (cadherin 2), and Vim (vimentin) mRNA using the Roche Universal Probe Library (Roche Applied Sciences, Burgess Hill, UK) [Apc forward primer: 5-CTTCGTGT ACGGCAGCTCTT-3', reverse primer: 5 '-GCAGTTTCATGC TTGC TCTG-3' (probe 127, catalog no.
In a study comparing MM samples from patients with short-term recurrence after surgery (STR) and patients with longer time to relapse, (9) the cadherin gene CDH2 was upregulated especially in the STR group.
Through collaboration between Harvard University, the Cummings School of Veterinary Medicine at Tufts, the University of Massachusetts Medical School and others, scientists discovered that the canine chromosome 7 location within the neural cadherin-2 gene, or CDH2, confers a high risk of susceptibility to the disorder.