CDH2

CDH2

A gene on chromosome 18q11.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH2 functions during gastrulation and is required for establishing left-right asymmetry. At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by CDH2; in the hippocampus, it may regulate dendritic spine density.
Mentioned in ?
References in periodicals archive ?
In a study comparing MM samples from patients with short-term recurrence after surgery (STR) and patients with longer time to relapse, (9) the cadherin gene CDH2 was upregulated especially in the STR group.
Through collaboration between Harvard University, the Cummings School of Veterinary Medicine at Tufts, the University of Massachusetts Medical School and others, scientists discovered that the canine chromosome 7 location within the neural cadherin-2 gene, or CDH2, confers a high risk of susceptibility to the disorder.
This highly significant association is the first genetic locus identified for any animal compulsive disorder, raising the intriguing possibility that CDH2 and other proteins are involved in human compulsive behaviours, including those observed in autism.
The chromosome 7 location most significantly associated with CCD is located within the neural cadherin-2 gene, CDH2.