CDH18

A gene on chromosome 5p14.3 that encodes cadherin 18, a so-called type-II (atypical) cadherin (which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins). It is expressed specifically in the CNS and is thought to be involved in synaptic adhesion, axon outgrowth and guidance.

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CDH24

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Classical cadherins can be further subdivided into the type I classical cadherins consisting of CDH1 (E-cad), CDH2 (N-cad), CDH3 (P-cad), CDH4 (R-cad), and CDH15 (M-cad); the type II classical cadherins include CDH5 (VE-cad), CDH6 (K-cad), CDH7, CDH8, CDH9 (T1-cad), CDH10 (T2-cad), CDH11 (OB-cad), CDH12 (N-cad-2), CDH18, CDH19, CDH20, CDH22, and CDH24.

The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction

All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).

Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

Other genetic studies of keratocystic odontogenic tumors have detected deletions within cadherin-related genes (CDH5 and CDH18), possibly providing an explanation for the frequently observed detachment of the cyst-lining epithelium from the under lying stroma, a histopathologic hallmark of these lesions (Figure 2).

An Overview of Molecular and Genetic Alterations in Selected Benign Odontogenic Disorders

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