Special AT-rich sequence-binding protein 2 (SATB2) and cadherin-17 (CDH17
) are new markers that have been increasingly used recently (Table 1).
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17
(LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).
Ren et al., "Targeting CDH17
suppresses tumor progression in gastric cancer by downregulating Wnt/[micro]-catenin signaling," PLoS ONE, vol.
In recent years, several intrinsic genetic factors such as expression of the cadherin-17 gene (CDH17
) have been implicated in the carcinogenesis and progression of human cancers, and have become a popular research topic (10).
The IHC markers of increasing clinical use are special AT-rich sequence-binding protein 2 (SATB2) and cadherin-17 (CDH17
) for gastrointestinal lineage, glypican-3 (GPC3) and heat shock protein 70 (HSP70) for liver malignancy (versus benign lesions), and the 4-marker panel of pVHL, maspin, S100P, and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) for pancreatic and biliary tract malignancy.
Cadherin 17 (CDH17
), also called liver-intestine cadherin, is a cell-adhesion protein that is transcriptionally regulated by CDX2, and is involved in tumor invasion and metastasis.
Is a More Sensitive Marker for Gastric Adenocarcinoma Than CK20 and CDX2.
While this study did not correlate CDH17
with prognosis or patient survival, it should be noted that other studies (14-16) have shown prognostic value for CDH17
in colon and in gastric adenocarcinoma.
A panel of immunomarkers that includes CK7, CK20, thyroid transcription factor 1 (TTF1), CDX2, cadherin-17 (CDH17
), special AT-rich sequence-binding protein 2 (SATB2), PR, PDX1, and PAX8 is useful in differentiating a P-NET from a NET of other organs, which was described in the Immunohistochemistry in Undifferentiated Neoplasm/Tumor of Uncertain Origin article by Lin and Liu.
Cadherin 17 (CDH17
) is also known as liver-intestine cadherin because it was originally discovered as a novel calcium-dependent cell adhesion molecule expressed in the liver and intestine of rats.
More recently, GATA binding protein 3 (GATA3), arginase 1 (ARG1), trefoil factor (TFF) 1, ankyrin repeat domain 30A (NY-BR-1), sal-like protein 4 (SALL4), special AT-rich sequence-binding protein 2 (SATB2), cadherin-17 (CDH17
), and von Hippel-Lindau tumor suppressor (pVHL) have been reported as useful as well.
), also known as Li-cadherin (liverintestine cadherin), is a member of the cadherin superfamily and is a calcium-dependent transmembrane glycoprotein.