Tumor-specific downregulation and methylation of the CDH13
(H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas.
Como ejemplo de esto estan los estudios en Chile, de los genes APAF1, ASSP1, p73 y FHIT,p15, p16, ESR1, IGSF4, SOCS1(9); en Colombia, de los genes RARB y DAPK;CDKN2B y DBC1(10);en Brasil, del gen CDKN2B (p15) (11) y en Espana de CDH1, p73, p16, p15, p57, NES-1, DKK-3, CDH13
, p14, TMS-1, Apaf-1, DAPK, Parkin, LATS-1(12).
Algunos de los genes estudiados en el contexto de hipermetilacion de sus promotores en cancer de pulmon incluyen: CDKNA/P16INK4a, RASSF1, MGMT, APC, DAPK, FHIT, CDH13
, RAR [beta], SHOX2, RUNX3, CDH1, TSCL1, ASC/TMS1, DAL1, PTEN, GSTP1.
2012) Methylation of HIN-1, RASSF1A, RIL and CDH13
in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
SNPs in four genes appear for three or more chemicals: GRIP1 (glutamate receptor interacting protein 1), which directs localization of transmembrane proteins; FMN2, a component of p21-based cell cycle arrest; DNER, a transmembrane protein associated with glioblastoma propagation; and the cell membrane cadherin CDH13
, an epithelial tumor suppressor.
A study of nearly 800 Finns jailed for both violent and non-violent crimes, and compared to the general population, found variants of two genes, called MAOA and CDH13
, to be "associated with extremely violent behaviour".
All tumors that were evaluated showed underexpression of SHH, TRAF3, ARHGAP4, DCC, CDH12, CDH13
, TDGF1, and TGFB1.
The study identified several SNPs in a region on chromosome 2 that previously had been linked to alcohol dependence, as well as SNPs in a gene called CDH13
that is located on chromosome 16 and the ADH gene ADH1C on chromosome 4.
To further explore the findings that promoter methylation of the certain tumor suppressor genes was associated with early recurrence in NSCLC, a prospective study was designed to analyze the methylation status of ten gene promoters (p16, CDH13
, RASSF1A, APC, MGMT, WIF-1, METH-2, GSTP1, SOCS3, DAPK) and correlate status with clinical features, pathologic stage, disease-free survival (DFS) and overall survival (OS).
The replication analyses was performed on two intronic CDH13
SNPs exhibiting the lowest or very low p-values in the discovery phase without being in high linkage disequilibrium with one other (top hit, rs232593, and rs17284098).
44) Several genes important in the pathogenesis of pancreatic cancer such as APC, (45) TSLC/IGSF4, (46) SOCS-1, (47) cyclin D2, (48) RASSF1A, (49) WWOX, (50) RUNX3, (51) CDH13
, (52) DUSP6, (53) HHIP, (54) and SLC5A8 (55) undergo aberrant methylation, leading to reduced expression or loss of expression.
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13
, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].