CDH13

CDH13

A gene on chromosome 16q23.3 that encodes a cadherin which lacks the cytoplasmic domain characteristic of other cadherins, and thus is not thought to be a cell–cell adhesion glycoprotein. CDH13 downregulates axon growth during neural differentiation, protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis.

Molecular pathology
CDH13 is hypermethylated in many cancers.
References in periodicals archive ?
The genes that are most widely studied in the context of promoter methylation in lung cancer are p16INK4a, RASSF1A, APC, RAR[beta], CDH1, CDH13, DAPK, FHIT, and MGMT.
Tumor-specific downregulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas.
Zhang, "The effect of celecoxib on DNA methylation of CDH13, TFPI2, and FSTL1 in squamous cell carcinoma of the esophagus in vivo," Anti-Cancer Drugs, vol.
Chen et al., "A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes," Diabetes, vol.
Ko, "Association of CDH13 genotypes/haplotypes with circulating adiponectin levels, metabolic syndrome, and related metabolic phenotypes: the role of the suppression effect," PLoS One, vol.
Como ejemplo de esto estan los estudios en Chile, de los genes APAF1, ASSP1, p73 y FHIT,p15, p16, ESR1, IGSF4, SOCS1(9); en Colombia, de los genes RARB y DAPK;CDKN2B y DBC1(10);en Brasil, del gen CDKN2B (p15) (11) y en Espana de CDH1, p73, p16, p15, p57, NES-1, DKK-3, CDH13, p14, TMS-1, Apaf-1, DAPK, Parkin, LATS-1(12).
The interaction between rs1909884 and rs17284390 is located within the gene cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) and the gene cadherin 13 (CDH13).
EBV latent LMP1 induces hypermethylation of promoter regions E-cadherin 13 (CDH13) and docking protein 1 through activation of DNMT1 in EBV-related gastric cancer, leading to suppression of gene expression.
Yoshimoto et al., "Tumor-specific down-regulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas," Modern Pathology, vol.
A study analyzed the DNA of almost 900 offenders in Finland and found those with MAOA gene, referred to as the warrior gene, and a variant of cadherin 13 (CDH13) were 13 times more likely to have a history of violent behavior.
Algunos de los genes estudiados en el contexto de hipermetilacion de sus promotores en cancer de pulmon incluyen: CDKNA/P16INK4a, RASSF1, MGMT, APC, DAPK, FHIT, CDH13, RAR [beta], SHOX2, RUNX3, CDH1, TSCL1, ASC/TMS1, DAL1, PTEN, GSTP1.
(2012) Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.