The genes that are most widely studied in the context of promoter methylation in lung cancer are p16INK4a, RASSF1A, APC, RAR[beta], CDH1, CDH13
, DAPK, FHIT, and MGMT.
Tumor-specific downregulation and methylation of the CDH13
(H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas.
Zhang, "The effect of celecoxib on DNA methylation of CDH13
, TFPI2, and FSTL1 in squamous cell carcinoma of the esophagus in vivo," Anti-Cancer Drugs, vol.
Chen et al., "A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13
that predicts cardiometabolic outcomes," Diabetes, vol.
Ko, "Association of CDH13
genotypes/haplotypes with circulating adiponectin levels, metabolic syndrome, and related metabolic phenotypes: the role of the suppression effect," PLoS One, vol.
Como ejemplo de esto estan los estudios en Chile, de los genes APAF1, ASSP1, p73 y FHIT,p15, p16, ESR1, IGSF4, SOCS1(9); en Colombia, de los genes RARB y DAPK;CDKN2B y DBC1(10);en Brasil, del gen CDKN2B (p15) (11) y en Espana de CDH1, p73, p16, p15, p57, NES-1, DKK-3, CDH13
, p14, TMS-1, Apaf-1, DAPK, Parkin, LATS-1(12).
The interaction between rs1909884 and rs17284390 is located within the gene cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) and the gene cadherin 13 (CDH13
EBV latent LMP1 induces hypermethylation of promoter regions E-cadherin 13 (CDH13
) and docking protein 1 through activation of DNMT1 in EBV-related gastric cancer, leading to suppression of gene expression.
Yoshimoto et al., "Tumor-specific down-regulation and methylation of the CDH13
(H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas," Modern Pathology, vol.
A study analyzed the DNA of almost 900 offenders in Finland and found those with MAOA gene, referred to as the warrior gene, and a variant of cadherin 13 (CDH13
) were 13 times more likely to have a history of violent behavior.
Algunos de los genes estudiados en el contexto de hipermetilacion de sus promotores en cancer de pulmon incluyen: CDKNA/P16INK4a, RASSF1, MGMT, APC, DAPK, FHIT, CDH13
, RAR [beta], SHOX2, RUNX3, CDH1, TSCL1, ASC/TMS1, DAL1, PTEN, GSTP1.
(2012) Methylation of HIN-1, RASSF1A, RIL and CDH13
in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.