CDH10

CDH10

A gene on chromosome 5p14.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH10 is a so-called type-II (atypical) cadherin—which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins—and is expressed in the brain and thought to be involved in synaptic adhesions, axon outgrowth and guidance.
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Classical cadherins can be further subdivided into the type I classical cadherins consisting of CDH1 (E-cad), CDH2 (N-cad), CDH3 (P-cad), CDH4 (R-cad), and CDH15 (M-cad); the type II classical cadherins include CDH5 (VE-cad), CDH6 (K-cad), CDH7, CDH8, CDH9 (T1-cad), CDH10 (T2-cad), CDH11 (OB-cad), CDH12 (N-cad-2), CDH18, CDH19, CDH20, CDH22, and CDH24.
Other cadherins that showed high expression levels were CDH7, CDH10, CDH11 and CDH20 (Fig.
While some of the remaining genes are involved in neurological processes or neural development (CALB2, CDH10, ENPP5, and FLRT2), others have been associated with cancer (AKR1B10, CALB2, CDH10, and CYB5R2), but only CYB5R2 has specifically been identified as a potential (epigenetic) marker for glioblastoma prognosis [37].
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).
The SNPs were located in chromosome 5 (5p14.1) between cadherin 10 (CDH10) and cadherin 9 (CDH9), two genes that encode neuronal cell-adhesion molecules.
Reporting online April 28 in the Annals of Human Genetics, the duo confirmed that ASD is strongly associated with genetic variations near CDH9 and CDH10.
London, Apr 29 (ANI): In the world's largest DNA scan for autism, US scientists have uncovered a new gene variant, called CDH10, which is highly common in children suffering from the disorder.
In partnership with 30 research institutions across the US, scientists scrutinized the activity of CDH10 and found that it is most active in key regions that support language, speech and interpreting social behaviour.
The two findings suggest that CDH10 plays a critical role in shaping the developing brain and may contribute to a prenatal risk of autism.
It was found that the variants sat on chromosome 5 between two genes, CDH9 and CDH10.
While CDH9's presence appeared minimal, the scientists discovered that CDH10 was most active in the fetal brain's frontal cortex, a region critical to language, social behaviour and complex thought processes such as judgment.
Our research suggests that CDH10 is switched on at a very early stage and plays an important role in regulating the developing brain.