LMNA

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LMNA

A gene on chromosome 1q22 that encodes lamin A/C, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNA mutations cause the so-called laminopathies—e.g., Charcot-Marie-Tooth disease type 2B1, progeria (Hutchinson-Gilford syndrome), dilated cardiomyopathy, Emery-Dreifuss muscular dystrophy type 2, familial partial lipodystrophy, limb-girdle muscular dystrophy type 1B, mandibuloacral dysplasia, and some cases of Werner syndrome.
References in periodicals archive ?
lt]) data show statistically significant reductions in strength values of FRP treated with CDDC (27% reduction) and the high concentration of CCA (25% reduction) when compared to other treatments and the untreated controls (Tables 4 and 5).
STARTING POINT: James Gill, left, of NRG and John Hildreth, CDDC business development executive, launch the new NETPark Affinity programme.
CDDC managing director Stewart Watkins said: "The company is an important employer in the area and has a superb, state-of-the-art fish-processing facility.
Stewart Watkins, managing director of CDDC who commissioned Dewjo'c, said: "Having worked with Dewjo'c on previous NETPark projects we were aware of their pedigree in designing and building for laboratory and office use.
While the status is dependent on quality and reviewed annually, CDDC will only award gold status to one company operating within a particular sector.
Stewart Watkins, managing director of CDDC, said: "This is the third time we have held the Solar Flair conference and it has rapidly gained a reputation for excellence within the photovoltaic field.
CDDC managing director Stewart Watkins said: "The Incubator provides these incredibly exciting early stage businesses with first-class support as they look to turn cutting-edge research into commercially viable companies.
CDDC managing director Stewart Watkins said: "The NETPark Incubator is specifically designed to support innovative companies like Global Management Platform and it's fantastic to see them already launching a new product.
Stewart Watkins, managing director of the County Durham Development Company (CDDC), said CDDC had arranged an urgent meeting with Electrolux to outline the support and expertise available, in an effort to ensure the long-term future of this "important employer in the county".
Stewart Watkins, CDDC managing director, said: "We are creating a 'NETPark without walls' which will bring the world-class services on offer at NETPark companies throughout County Durham and across the North-east at the click of a mouse.
As a market leader in sustainable construction, Willmott Dixon is proud to be working in partnership with a forward-thinking client like CDDC which is equally keen to ensure the construction is sourced responsibly.