PIGU

(redirected from CDC91L1)

PIGU

A gene on chromosome 20q11.22 that encodes a component of the glycosylphosphatidylinositol (GPI) transamidase complex possibly involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
References in periodicals archive ?
For example, the "CDC91L1 gene" was commonly noted as related to bladder cancer in the summarized SemRep output but was not noted in the OMIM and Genetics Home Reference records consulted in creating the reference standard, even though one of the GeneRIFs in Entrez Gene for CDC91L1 in Homo sapiens notes the following: "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer" (PMID: 15034568, published within the time frame of this study).
4) Relying on the knowledge that cancer begins by an activation or amplification of these oncogenes, the scientists traced what is known as a germline translocation, or break, in the DNA of a bladder-cancer patient, and found that the overexpression of CDC91L1 was the only consequence of that break.
CDC91L1 (PIGU) is a newly discovered oncogene in human bladder cancer.